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Effect of Domperidone on Insufficient Lactation in Puerperal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
المؤلفون المشاركون
Koren, Gideon
Moretti, Myla E.
Osadchy, Alla
المصدر
Obstetrics and Gynecology International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
There is a controversy within the medical community regarding the role of domperidone as a galactagogue and the drug has been removed from the US market owing to safety concerns.
Objective.
To perform a systematic review and meta-analysis of the available data assessing the effect of domperidone on breast milk production in women experiencing insufficient lactation.
Study Selection.
Randomized controlled trials (RCTs) examining the effect of domperidone on breast milk production of puerperal women were eligible for inclusion.
Data Analysis.
Absolute and relative changes from baseline were calculated for individual studies and pooled using a random effects model.
Results.
Three RCTs including 78 participants met the inclusion criteria.
All showed a statistically significant increase in breast milk production following treatment with domperidone.
The analysis of pooled data demonstrated a statistically significant relative increase of 74.72% (95% CI=54.57; 94.86,P<0.00001) in daily milk production with domperidone treatment compared to placebo.
No maternal or neonatal adverse events were observed in any of the trials.
Conclusions.
Evidence from a few small RCTs of moderate to high quality suggests that domperidone produces a greater increase in breast milk supply than placebo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Osadchy, Alla& Moretti, Myla E.& Koren, Gideon. 2012. Effect of Domperidone on Insufficient Lactation in Puerperal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Obstetrics and Gynecology International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029967
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Osadchy, Alla…[et al.]. Effect of Domperidone on Insufficient Lactation in Puerperal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Obstetrics and Gynecology International No. 2012 (Dec. 2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1029967
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Osadchy, Alla& Moretti, Myla E.& Koren, Gideon. Effect of Domperidone on Insufficient Lactation in Puerperal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Obstetrics and Gynecology International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029967
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029967
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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