The Fetal Safety of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers
المؤلفون المشاركون
Koren, Gideon
Moretti, Myla E.
Caprara, Daniela
Drehuta, Irina
Yeung, Emily
Cheung, Stefanie
Federico, Lisa
المصدر
Obstetrics and Gynecology International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are known to cause fetal renal damage in pregnancy.
Due to conflicting reports in the literature, their safety after first trimester exposure has been debated.
Our aim was to determine whether the use of ACE inhibitors or ARBs in the first trimester of pregnancy is associated with an increased risk for major malformations or other adverse outcomes.
All subjects were prospectively enrolled from among women contacting a teratogen information service.
At initial contact, details of maternal medical history and exposures were collected and follow-up interviews were conducted to ascertain pregnancy outcomes.
Two comparator groups, women with hypertension treated with other antihypertensives, and healthy controls were also recruited.
Baseline maternal characteristics were not different among the three groups.
There were no differences in rates of major malformations.
Both the ACE-ARBs and disease-matched groups exhibited significantly lower birth weight and gestational ages than the healthy controls (P<0.001 for both variables).
There was a significantly higher rate of miscarriage noted in the ACE/ARB group (P<0.001).
These results suggest that ACE inhibitors/ARBs are not major human teratogens; however, they may be associated with an increased risk for miscarriage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moretti, Myla E.& Caprara, Daniela& Drehuta, Irina& Yeung, Emily& Cheung, Stefanie& Federico, Lisa…[et al.]. 2011. The Fetal Safety of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers. Obstetrics and Gynecology International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1029968
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moretti, Myla E.…[et al.]. The Fetal Safety of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers. Obstetrics and Gynecology International No. 2012 (Dec. 2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1029968
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moretti, Myla E.& Caprara, Daniela& Drehuta, Irina& Yeung, Emily& Cheung, Stefanie& Federico, Lisa…[et al.]. The Fetal Safety of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers. Obstetrics and Gynecology International. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1029968
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029968
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر