Alpha-Lipoic Acid Attenuates Renal Injury in Rats with Obstructive Nephropathy
المؤلفون المشاركون
Wongmekiat, Orawan
Thamprasert, Kamthorn
Leelarungrayub, Donrawee
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This study was established to determine the possible protective effects of alpha-lipoic acid (ALA), a powerful antioxidant, on renal injury in obstructive nephropathy.
Male Sprague-Dawley rats were assigned into sham-operated unilateral ureteral obstruction (UUO) and UUO treated with ALA groups.
ALA 60 mg/kg was injected intraperitoneally 2 days before UUO induction and continued afterward for 7 days.
Renal function, oxidative stress markers, nitric oxide, transforming growth factor-1 (TGF-β1), and histological changes were evaluated at the end of the experiment.
Obstruction of the ureter resulted in renal dysfunction as indicated by significant increases in blood urea nitrogen and serum creatinine.
Nonobstructed contralateral kidneys in all groups examined did not show any morphological or biochemical alterations.
In untreated UUO group, the obstructed kidney developed marked hydronephrosis, leukocyte infiltration, and severe interstitial fibrosis.
These functional and structural changes were associated with significant increases in tissue levels of malondialdehyde, nitric oxide, and TGF-β1 but decreases in reduced glutathione and total antioxidant capacity.
Pretreatment with ALA significantly minimized all the changes elicited by ureteral obstruction.
These findings demonstrate that ALA supplementation attenuates renal injury in rats with obstructive nephropathy and further suggest that oxidative stress inhibition is likely to be involved in the beneficial effects of this compound.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wongmekiat, Orawan& Leelarungrayub, Donrawee& Thamprasert, Kamthorn. 2013. Alpha-Lipoic Acid Attenuates Renal Injury in Rats with Obstructive Nephropathy. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030103
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wongmekiat, Orawan…[et al.]. Alpha-Lipoic Acid Attenuates Renal Injury in Rats with Obstructive Nephropathy. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030103
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wongmekiat, Orawan& Leelarungrayub, Donrawee& Thamprasert, Kamthorn. Alpha-Lipoic Acid Attenuates Renal Injury in Rats with Obstructive Nephropathy. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030103
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030103
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر