Snake Venom PLA2s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules
المؤلفون المشاركون
Martins Soares, Andreimar
da Silva, Saulo Luís
Santos, J. D. L.
Xavier, B. M.
Almeida, J. R.
Resende, L. M.
Stábeli, Rodrigo G.
Marcussi, Silvana
Calderon, Leonardo A.
Martins, W.
Marchi-Salvador, D. P.
Carvalho, Bruna M. A.
Marangoni, Sérgio
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Ophidian envenomation is an important health problem in Brazil and other South American countries.
In folk medicine, especially in developing countries, several vegetal species are employed for the treatment of snakebites in communities that lack prompt access to serum therapy.
However, the identification and characterization of the effects of several new plants or their isolated compounds, which are able to inhibit the activities of snake venom, are extremely important and such studies are imperative.
Snake venom contains several organic and inorganic compounds; phospholipases A2 (PLA2s) are one of the principal toxic components of venom.
PLA2s display a wide variety of pharmacological activities, such as neurotoxicity, myotoxicity, cardiotoxicity, anticoagulant, hemorrhagic, and edema-inducing effects.
PLA2 inhibition is of pharmacological and therapeutic interests as these enzymes are involved in several inflammatory diseases.
This review describes the results of several studies of plant extracts and their isolated active principles, when used against crude snake venoms or their toxic fractions.
Isolated inhibitors, such as steroids, terpenoids, and phenolic compounds, are able to inhibit PLA2s from different snake venoms.
The design of specific inhibitors of PLA2s might help in the development of new pharmaceutical drugs, more specific antivenom, or even as alternative approaches for treating snakebites.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carvalho, Bruna M. A.& Santos, J. D. L.& Xavier, B. M.& Almeida, J. R.& Resende, L. M.& Martins, W.…[et al.]. 2013. Snake Venom PLA2s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030130
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carvalho, Bruna M. A.…[et al.]. Snake Venom PLA2s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030130
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carvalho, Bruna M. A.& Santos, J. D. L.& Xavier, B. M.& Almeida, J. R.& Resende, L. M.& Martins, W.…[et al.]. Snake Venom PLA2s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030130
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030130
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر