What Is the Role of Apelin regarding Cardiovascular Risk and Progression of Renal Disease in Type 2 Diabetic Patients with Diabetic Nephropathy?
المؤلفون المشاركون
Fragoso, André
Silva, Claudia
Tavares, Nelson
Guilherme, Patrícia
Santos, Nélio
Rato, Fátima
Camacho, Ana
Cavaco, Cidália
Pereira, Victor
Faísca, Marilia
Ataíde, João
Jesus, Ilídio
Neves, Pedro Leão
Viegas, Carla S. B.
Silva, Ana Paula
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aims.
To evaluate the association of different apelin levels with cardiovascular mortality, hospitalization, renal function, and cardiovascular risk factors in type 2 diabetic patients with mild to moderate CKD.
Methods.
An observational, prospective study involving 150 patients divided into groups according to baseline apelin levels: 1≤98 pg/mL, 2 = 98–328 pg/mL, and 3≥329 pg/mL.
Baseline characteristics were analyzed and compared.
Multivariate Cox regression was used to find out predictors of cardiovascular mortality, and multivariate logistic regression was used to find out predictors of hospitalization and disease progression.
Simple linear regressions and Pearson correlations were used to investigate correlations between apelin and renal disease and cardiovascular risk factors.
Results.
Patients’ survival at 83 months in groups 1, 2, and 3 was 39%, 40%, and 71.2%, respectively (P=0.046).
Apelin, age, and eGFR were independent predictors of mortality, and apelin, creatinine, eGFR, resistin, and visfatin were independent predictors of hospitalization.
Apelin levels were negatively correlated with cardiovascular risk factors and positively correlated with eGFR.
Patients with lower apelin levels were more likely to start a depurative technique.
Conclusions.
Apelin levels might have a significant clinical use as a marker/predictor of cardiovascular mortality and hospitalization or even as a therapeutic agent for CKD patients with cardiovascular disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Silva, Ana Paula& Fragoso, André& Silva, Claudia& Viegas, Carla S. B.& Tavares, Nelson& Guilherme, Patrícia…[et al.]. 2013. What Is the Role of Apelin regarding Cardiovascular Risk and Progression of Renal Disease in Type 2 Diabetic Patients with Diabetic Nephropathy?. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030223
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Silva, Ana Paula…[et al.]. What Is the Role of Apelin regarding Cardiovascular Risk and Progression of Renal Disease in Type 2 Diabetic Patients with Diabetic Nephropathy?. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030223
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Silva, Ana Paula& Fragoso, André& Silva, Claudia& Viegas, Carla S. B.& Tavares, Nelson& Guilherme, Patrícia…[et al.]. What Is the Role of Apelin regarding Cardiovascular Risk and Progression of Renal Disease in Type 2 Diabetic Patients with Diabetic Nephropathy?. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030223
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030223
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر