The Steady-State Serum Concentration of Genistein Aglycone Is Affected by Formulation: A Bioequivalence Study of Bone Products
المؤلفون المشاركون
Bitto, Alessandra
Squadrito, Francesco
Levy, Robert M.
Polito, Francesca
Russo, Silvia
D'Anna, Rosario
Burnett, Bruce P.
Pillai, Lakshmi
Altavilla, Domenica
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
An FDA-regulated, prescription medical food (Fosteum; 27 mg natural genistein, 200 IU cholecalciferol, 20 mg citrated zinc bisglycinate (4 mg elemental zinc) per capsule) and an over-the-counter (OTC) supplement (Citracal Plus Bone Density Builder; 27 mg synthetic genistein, 600 mg elemental calcium (calcium citrate), 400 IU vitamin D3, 50 mg magnesium, 7.5 mg zinc, 1 mg copper, 75 μg molybdenum, 250 μg boron per two tablets) were compared to a clinically proven bone formulation (27 mg natural genistein, 400 IU cholecalciferol, 500 mg elemental calcium (calcium carbonate) per tablet; the Squadrito formulation) in an 8-day steady-state pharmacokinetic (PK) study of healthy postmenopausal women (n=30) randomized to receive 54 mg of genistein per day.
Trough serum samples were obtained before the final dose on the morning of the ninth day followed by sampling at 1, 2, 4, 6, 8, 10, 12, 24, 36, 48, 72, and 96 hrs.
Total serum genistein, after β-glucuronidase/sulfatase digestion, was measured by time-resolved fluorometric assay.
Maximal time (Tmax), concentration (Cmax), half-life (T1/2), and area under the curve (AUC) were determined for genistein in each formulation.
Fosteum and the Squadrito study formulation were equivalent for genistein Tmax (2 hrs), Cmax (0.7 μM), T1/2 (18±6.9 versus 21±4.9 hrs), and AUC (9221±413 versus 9818±1370 ng·hr/mL).
The OTC supplement’s synthetically derived genistein, however, showed altered Tmax (6 hrs), Cmax (0.57 μM), T1/2 (8.3±1.9 hrs), and AUC (6474±287 ng·hr/mL).
Differences in uptake may be due to multiple ingredients in the OTC supplement which interfere with genistein absorption.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Burnett, Bruce P.& Polito, Francesca& Russo, Silvia& D'Anna, Rosario& Pillai, Lakshmi& Squadrito, Francesco…[et al.]. 2012. The Steady-State Serum Concentration of Genistein Aglycone Is Affected by Formulation: A Bioequivalence Study of Bone Products. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030269
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Burnett, Bruce P.…[et al.]. The Steady-State Serum Concentration of Genistein Aglycone Is Affected by Formulation: A Bioequivalence Study of Bone Products. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030269
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Burnett, Bruce P.& Polito, Francesca& Russo, Silvia& D'Anna, Rosario& Pillai, Lakshmi& Squadrito, Francesco…[et al.]. The Steady-State Serum Concentration of Genistein Aglycone Is Affected by Formulation: A Bioequivalence Study of Bone Products. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030269
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030269
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر