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Changes in the Mucus Barrier during Cisplatin-Induced Intestinal Mucositis in Rats
المؤلفون المشاركون
Koizumi, Wasaburo
Yamamoto, Hajime
Ishihara, Kazuhiko
Takeda, Yuko
Ichikawa, Takafumi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
Gastrointestinal mucositis is a frequent complication of antineoplastic chemotherapy, but the effects of chemotherapy on mucosal defense mechanisms remain poorly understood.
We studied the effects of cisplatin on mucin, one of the principal defense factors of the gastrointestinal mucosa, and evaluated the efficacy of two different types of H2-receptor antagonists against cisplatin-induced mucositis.
Methods.
Cisplatin (6 mg/kg) was administered intravenously to rats (day 0).
The rats were sacrificed 1, 3, 7, and 11 days after treatment, and their stomach, jejunum, ileum, and colon were removed.
Immunoreactivity of the mucosa was compared with the use of anti-mucin monoclonal antibody.
To evaluate the efficacy of H2-receptor antagonists, either famotidine (3 mg/kg) or lafutidine (30 mg/kg) was given orally once daily on days 0, 1, and 2.
Histological and biochemical findings were compared among the groups to assess effects on cisplatin-induced injury.
Results.
Cisplatin significantly altered the immunoreactivity and content of mucin in the small intestinal mucosa, especially in the ileum.
Lafutidine protected against cisplatin-induced mucosal injury and attenuated decreased mucin accumulation.
Conclusion.
Cisplatin appears to alter the mucus barrier function in the intestinal mucosa.
Lafutidine might effectively prevent chemotherapy-induced mucositis by activating intestinal mucus cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yamamoto, Hajime& Ishihara, Kazuhiko& Takeda, Yuko& Koizumi, Wasaburo& Ichikawa, Takafumi. 2013. Changes in the Mucus Barrier during Cisplatin-Induced Intestinal Mucositis in Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030271
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yamamoto, Hajime…[et al.]. Changes in the Mucus Barrier during Cisplatin-Induced Intestinal Mucositis in Rats. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030271
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yamamoto, Hajime& Ishihara, Kazuhiko& Takeda, Yuko& Koizumi, Wasaburo& Ichikawa, Takafumi. Changes in the Mucus Barrier during Cisplatin-Induced Intestinal Mucositis in Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030271
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030271
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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