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MMP1, MMP9, and COX2 Expressions in Promonocytes Are Induced by Breast Cancer Cells and Correlate with Collagen Degradation, Transformation-Like Morphological Changes in MCF-10A Acini, and Tumor Aggressiveness
المؤلفون المشاركون
Arriaga-Pizano, Lourdes
Utrera-Barillas, D.
Benítez-Bribiesca, L.
Velázquez, J. R.
Monroy-García, A.
Reyes-Maldonado, E.
Domínguez-López, M. L.
Piña-Sánchez, Patricia
Espinoza-Sánchez, N. A.
Chimal-Ramírez, G. K.
Fuentes-Pananá, Ezequiel M.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-09
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Tumor-associated immune cells often lack immune effector activities, and instead they present protumoral functions.
To understand how tumors promote this immunological switch, invasive and noninvasive breast cancer cell (BRC) lines were cocultured with a promonocytic cell line in a Matrigel-based 3D system.
We hypothesized that if communication exists between tumor and immune cells, coculturing would result in augmented expression of genes associated with tumor malignancy.
Upregulation of proteases MMP1 and MMP9 and inflammatory COX2 genes was found likely in response to soluble factors.
Interestingly, changes were more apparent in promonocytes and correlated with the aggressiveness of the BRC line.
Increased gene expression was confirmed by collagen degradation assays and immunocytochemistry of prostaglandin 2, a product of COX2 activity.
Untransformed MCF-10A cells were then used as a sensor of soluble factors with transformation-like capabilities, finding that acini formed in the presence of supernatants of the highly aggressive BRC/promonocyte cocultures often exhibited total loss of the normal architecture.
These data support that tumor cells can modify immune cell gene expression and tumor aggressiveness may importantly reside in this capacity.
Modeling interactions in the tumor stroma will allow the identification of genes useful as cancer prognostic markers and therapy targets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chimal-Ramírez, G. K.& Espinoza-Sánchez, N. A.& Utrera-Barillas, D.& Benítez-Bribiesca, L.& Velázquez, J. R.& Arriaga-Pizano, Lourdes…[et al.]. 2013. MMP1, MMP9, and COX2 Expressions in Promonocytes Are Induced by Breast Cancer Cells and Correlate with Collagen Degradation, Transformation-Like Morphological Changes in MCF-10A Acini, and Tumor Aggressiveness. BioMed Research International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1030278
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chimal-Ramírez, G. K.…[et al.]. MMP1, MMP9, and COX2 Expressions in Promonocytes Are Induced by Breast Cancer Cells and Correlate with Collagen Degradation, Transformation-Like Morphological Changes in MCF-10A Acini, and Tumor Aggressiveness. BioMed Research International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1030278
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chimal-Ramírez, G. K.& Espinoza-Sánchez, N. A.& Utrera-Barillas, D.& Benítez-Bribiesca, L.& Velázquez, J. R.& Arriaga-Pizano, Lourdes…[et al.]. MMP1, MMP9, and COX2 Expressions in Promonocytes Are Induced by Breast Cancer Cells and Correlate with Collagen Degradation, Transformation-Like Morphological Changes in MCF-10A Acini, and Tumor Aggressiveness. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1030278
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030278
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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