Actin Cytoskeleton Manipulation by Effector Proteins Secreted by Diarrheagenic Escherichia coli Pathotypes
المؤلفون المشاركون
Serapio-Palacios, Antonio
Ugalde-Silva, Paul
Tapia-Pastrana, Gabriela
Chavez-Dueñas, Lucia
Navarro-Garcia, Fernando
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-22، 22ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-30
دولة النشر
مصر
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
The actin cytoskeleton is a dynamic structure necessary for cell and tissue organization, including the maintenance of epithelial barriers.
Disruption of the epithelial barrier coincides with alterations of the actin cytoskeleton in several disease states.
These disruptions primarily affect the paracellular space, which is normally regulated by tight junctions.
Thereby, the actin cytoskeleton is a common and recurring target of bacterial virulence factors.
In order to manipulate the actin cytoskeleton, bacteria secrete and inject toxins and effectors to hijack the host cell machinery, which interferes with host-cell pathways and with a number of actin binding proteins.
An interesting model to study actin manipulation by bacterial effectors is Escherichia coli since due to its genome plasticity it has acquired diverse genetic mobile elements, which allow having different E.
coli varieties in one bacterial species.
These E.
coli pathotypes, including intracellular and extracellular bacteria, interact with epithelial cells, and their interactions depend on a specific combination of virulence factors.
In this paper we focus on E.
coli effectors that mimic host cell proteins to manipulate the actin cytoskeleton.
The study of bacterial effector-cytoskeleton interaction will contribute not only to the comprehension of the molecular causes of infectious diseases but also to increase our knowledge of cell biology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Navarro-Garcia, Fernando& Serapio-Palacios, Antonio& Ugalde-Silva, Paul& Tapia-Pastrana, Gabriela& Chavez-Dueñas, Lucia. 2012. Actin Cytoskeleton Manipulation by Effector Proteins Secreted by Diarrheagenic Escherichia coli Pathotypes. BioMed Research International،Vol. 2013, no. 2013, pp.1-22.
https://search.emarefa.net/detail/BIM-1030450
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Navarro-Garcia, Fernando…[et al.]. Actin Cytoskeleton Manipulation by Effector Proteins Secreted by Diarrheagenic Escherichia coli Pathotypes. BioMed Research International No. 2013 (2013), pp.1-22.
https://search.emarefa.net/detail/BIM-1030450
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Navarro-Garcia, Fernando& Serapio-Palacios, Antonio& Ugalde-Silva, Paul& Tapia-Pastrana, Gabriela& Chavez-Dueñas, Lucia. Actin Cytoskeleton Manipulation by Effector Proteins Secreted by Diarrheagenic Escherichia coli Pathotypes. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-22.
https://search.emarefa.net/detail/BIM-1030450
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030450
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر