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Effect of Folic Acid and Vitamin B12 on Pemetrexed Antifolate Chemotherapy in Nutrient Lung Cancer Cells
المؤلفون المشاركون
Chang, Gee-Chen
Huang, Yi-Rou
Chiu, Ling-Yen
Sheu, Gwo-Tarng
Yang, Tsung-Ying
Hsu, Shih-Lan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Pemetrexed (MTA) is a multitargeted antifolate drug approved for lung cancer therapy.
Clinically, supplementation with high doses of folic acid (FA) and vitamin B12 (VB12) lowers MTA cytotoxicities.
An antagonistic effect of FA/VB12 on MTA efficacy has been proposed.
However, patients who receive FA/VB12 show better tolerance to MTA with improved survival.
The aims of this study are to investigate the modulation of FA and VB12 on MTA drug efficacy in human nonsmall cell lung cancer (NSCLC) cell lines.
The sensitivities of cells, apoptosis, and MTA-regulated proteins were characterized to determine the possible effects of high doses of FA and VB12 on MTA efficacy.
MTA has the lowest efficacy under 10% serum conditions.
However, supplementation with FA and VB12 individually and additively reversed the insensitivity of NSCLC cells to MTA treatment with 10% serum.
The enhanced sensitivities of cells following FA/VB12 treatment were correlated with increasing apoptosis and were specific to MTA but not to 5-fluorouracil (5-FU).
Enhanced sensitivity was also associated with p21WAF1/Cip1 expression level.
Our results revealed no antagonistic effect of high doses of FA/VB12 on MTA efficacy in cancer cells grown in nutrient medium.
Furthermore, these data may partially explain why supplementation of FA and VB12 resulted in better survival in MTA-treated patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Tsung-Ying& Chang, Gee-Chen& Hsu, Shih-Lan& Huang, Yi-Rou& Chiu, Ling-Yen& Sheu, Gwo-Tarng. 2013. Effect of Folic Acid and Vitamin B12 on Pemetrexed Antifolate Chemotherapy in Nutrient Lung Cancer Cells. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030488
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Tsung-Ying…[et al.]. Effect of Folic Acid and Vitamin B12 on Pemetrexed Antifolate Chemotherapy in Nutrient Lung Cancer Cells. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030488
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Tsung-Ying& Chang, Gee-Chen& Hsu, Shih-Lan& Huang, Yi-Rou& Chiu, Ling-Yen& Sheu, Gwo-Tarng. Effect of Folic Acid and Vitamin B12 on Pemetrexed Antifolate Chemotherapy in Nutrient Lung Cancer Cells. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030488
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030488
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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