A Comparison of the Biological Features of Prostate Cancer with (PSA+, PSMA+) Profile according to RKIP
المؤلفون المشاركون
Ben Jemaa, Awatef
Bouraoui, Yosra
Sallami, Sataa
Nouira, Yassine
Oueslati, Ridha
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate differences in the biological features of the most immunoexpressed prostate cancer (PC) profiles (PSA+, PSMA+) according to the RKIP.
Methods.
19 PC with dominant Gleason grade ≥8 were studied.
Expression of PSA, PSMA, RKIP, Raf-1, MEK-1, ERK-1, ERK-2, p-Akt (T308), p-Akt (S473), NF-κB p50, and NF-κBp65 were detected immunohistochemically.
Results.
Loss of RKIP in the most immunoexpressed PC (PSA+, PSMA+) profile was associated with increased levels of PSA and PSMA expression.
Intensities of immunoreactions to PSA and PSMA were higher in cancer cells negative for RKIP (12.51 ± 1.6 and 34.95 ± 1.92) compared to those positive for RKIP (4.68 ± 1.11 and 28.56 ± 0.91).
In parallel, missing RKIP expression in PC patients with PSA+, PSMA+ profile was connected with increased components of both Raf-1/MEK/ERK and NF-κB (p65/p50), whereas Akt is activated independently of RKIP.
Conclusions.
Although characterized by the same (PSA+, PSMA+) profile, PC phenotype missing the RKIP related to invasive potential and greater biological aggressiveness reflected in overexpression of components of Raf-1/MEK/ERK and NF-κB (p65/p50) in which Akt is activated independently of RKIP.
Taking into account the PC phenotypes according to RKIP among PSA-PSMA profiles may improve distinguishing them from cancers that will become more aggressive and therefore adapt the therapeutic strategies in those patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ben Jemaa, Awatef& Bouraoui, Yosra& Sallami, Sataa& Nouira, Yassine& Oueslati, Ridha. 2013. A Comparison of the Biological Features of Prostate Cancer with (PSA+, PSMA+) Profile according to RKIP. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030521
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ben Jemaa, Awatef…[et al.]. A Comparison of the Biological Features of Prostate Cancer with (PSA+, PSMA+) Profile according to RKIP. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030521
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ben Jemaa, Awatef& Bouraoui, Yosra& Sallami, Sataa& Nouira, Yassine& Oueslati, Ridha. A Comparison of the Biological Features of Prostate Cancer with (PSA+, PSMA+) Profile according to RKIP. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030521
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030521
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر