Synthesis and Biological Evaluation of O-[3-18F-fluoropropyl]-α-methyl Tyrosine in Mesothelioma-Bearing Rodents
المؤلفون المشاركون
Shih, I-Hong
Duan, Xu-Dong
Yu, Dong-Fang
Kong, Fan-Lin
Yang, David J.
Zhang, Yin-Han
Ali, Mohammad S.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Radiolabeled tyrosine analogs enter cancer cells via upregulated amino acid transporter system and have been shown to be superior to 18F-fluoro-2-deoxy-D-glucose (18F-FDG) in differential diagnosis in cancers.
In this study, we synthesized O-[3-19F-fluoropropyl]-α-methyl tyrosine (19F-FPAMT) and used manual and automated methods to synthesize O-[3-18F-fluoropropyl]-α-methyl tyrosine (18F-FPAMT) in three steps: nucleophilic substitution, deprotection of butoxycarbonyl, and deesterification.
Manual and automated synthesis methods produced 18F-FPAMT with a radiochemical purity >96%.
The decay-corrected yield of 18F-FPAMT by manual synthesis was 34% at end-of-synthesis (88 min).
The decay-corrected yield of 18F-FPAMT by automated synthesis was 15% at end-of-synthesis (110 min).
18F-FDG and 18F-FPAMT were used for in vitro and in vivo studies to evaluate the feasibility of 18F-FPAMT for imaging rat mesothelioma (IL-45).
In vitro studies comparing 18F-FPAMT with 18F-FDG revealed that 18F-FDG had higher uptake than that of 18F-FPAMT, and the uptake ratio of 18F-FPAMT reached the plateau after being incubated for 60 min.
Biodistribution studies revealed that the accumulation of 18F-FPAMT in the heart, lungs, thyroid, spleen, and brain was significantly lower than that of 18F-FDG.
There was poor bone uptake in 18F-FPAMT for up to 3 hrs suggesting its in vivo stability.
The imaging studies showed good visualization of tumors with 18F-FPAMT.
Together, these results suggest that 18F-FPAMT can be successfully synthesized and has great potential in mesothelioma imaging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shih, I-Hong& Kong, Fan-Lin& Ali, Mohammad S.& Zhang, Yin-Han& Yu, Dong-Fang& Duan, Xu-Dong…[et al.]. 2013. Synthesis and Biological Evaluation of O-[3-18F-fluoropropyl]-α-methyl Tyrosine in Mesothelioma-Bearing Rodents. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030562
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shih, I-Hong…[et al.]. Synthesis and Biological Evaluation of O-[3-18F-fluoropropyl]-α-methyl Tyrosine in Mesothelioma-Bearing Rodents. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030562
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shih, I-Hong& Kong, Fan-Lin& Ali, Mohammad S.& Zhang, Yin-Han& Yu, Dong-Fang& Duan, Xu-Dong…[et al.]. Synthesis and Biological Evaluation of O-[3-18F-fluoropropyl]-α-methyl Tyrosine in Mesothelioma-Bearing Rodents. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030562
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030562
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر