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Predicting Drugs Side Effects Based on Chemical-Chemical Interactions and Protein-Chemical Interactions
المؤلفون المشاركون
Zhang, Jian
Zheng, Mingyue
Chou, Kuo-Chen
Huang, Tao
Feng, Kai-Yan
Chen, Lei
Cai, Yu-Dong
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
A drug side effect is an undesirable effect which occurs in addition to the intended therapeutic effect of the drug.
The unexpected side effects that many patients suffer from are the major causes of large-scale drug withdrawal.
To address the problem, it is highly demanded by pharmaceutical industries to develop computational methods for predicting the side effects of drugs.
In this study, a novel computational method was developed to predict the side effects of drug compounds by hybridizing the chemical-chemical and protein-chemical interactions.
Compared to most of the previous works, our method can rank the potential side effects for any query drug according to their predicted level of risk.
A training dataset and test datasets were constructed from the benchmark dataset that contains 835 drug compounds to evaluate the method.
By a jackknife test on the training dataset, the 1st order prediction accuracy was 86.30%, while it was 89.16% on the test dataset.
It is expected that the new method may become a useful tool for drug design, and that the findings obtained by hybridizing various interactions in a network system may provide useful insights for conducting in-depth pharmacological research as well, particularly at the level of systems biomedicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Lei& Huang, Tao& Zhang, Jian& Zheng, Mingyue& Feng, Kai-Yan& Cai, Yu-Dong…[et al.]. 2013. Predicting Drugs Side Effects Based on Chemical-Chemical Interactions and Protein-Chemical Interactions. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030587
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Lei…[et al.]. Predicting Drugs Side Effects Based on Chemical-Chemical Interactions and Protein-Chemical Interactions. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030587
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Lei& Huang, Tao& Zhang, Jian& Zheng, Mingyue& Feng, Kai-Yan& Cai, Yu-Dong…[et al.]. Predicting Drugs Side Effects Based on Chemical-Chemical Interactions and Protein-Chemical Interactions. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030587
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030587
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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