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Preparation and Characterization of a Gastric Floating Dosage Form of Capecitabine
المؤلفون المشاركون
Kadivar, Ali
Taghizadeh Davoudi, Ehsan
Ibrahim Noordin, Mohamed
Kamalidehghan, Behnam
Farjam, Abdoreza Soleimani
Akbari Javar, Hamid
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Gastrointestinal disturbances, such as nausea and vomiting, are considered amongst the main adverse effects associated with oral anticancer drugs due to their fast release in the gastrointestinal tract (GIT).
Sustained release formulations with proper release profiles can overcome some side effects of conventional formulations.
The current study was designed to prepare sustained release tablets of Capecitabine, which is approved by the Food and Drug Administration (FDA) for the treatment of advanced breast cancer, using hydroxypropyl methylcellulose (HPMC), carbomer934P, sodium alginate, and sodium bicarbonate.
Tablets were prepared using the wet granulation method and characterized such that floating lag time, total floating time, hardness, friability, drug content, weight uniformity, and in vitro drug release were investigated.
The sustained release tablets showed good hardness and passed the friability test.
The tablets’ floating lag time was determined to be 30–200 seconds, and it floated more than 24 hours and released the drug for 24 hours.
Then, the stability test was done and compared with the initial samples.
In conclusion, by adjusting the right ratios of the excipients including release-retarding gel-forming polymers like HPMC K4M, Na alginate, carbomer934P, and sodium bicarbonate, sustained release Capecitabine floating tablet was formulated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Taghizadeh Davoudi, Ehsan& Ibrahim Noordin, Mohamed& Kadivar, Ali& Kamalidehghan, Behnam& Farjam, Abdoreza Soleimani& Akbari Javar, Hamid. 2013. Preparation and Characterization of a Gastric Floating Dosage Form of Capecitabine. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030598
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Taghizadeh Davoudi, Ehsan…[et al.]. Preparation and Characterization of a Gastric Floating Dosage Form of Capecitabine. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030598
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Taghizadeh Davoudi, Ehsan& Ibrahim Noordin, Mohamed& Kadivar, Ali& Kamalidehghan, Behnam& Farjam, Abdoreza Soleimani& Akbari Javar, Hamid. Preparation and Characterization of a Gastric Floating Dosage Form of Capecitabine. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030598
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030598
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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