Angiotensin II AT1 Receptors Are Involved in Neuronal Activation Induced by Amphetamine in a Two-Injection Protocol
المؤلفون المشاركون
Bregonzio, Claudia
Paz, Maria Constanza
Marchese, Natalia Andrea
Cancela, Liliana M.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
It was already found that Ang II AT1 receptors are involved in the neuroadaptative changes induced by a single exposure to amphetamine, and such changes are related to the development of behavioral and neurochemical sensitization.
The induction of the immediately early gene c-fos has been used to define brain activated areas by amphetamine.
Our aim was to evaluate the participation of AT1 receptors in the neuronal activation induced by amphetamine sensitization.
The study examined the c-fos expression in mesocorticolimbic areas induced by amphetamine challenge (0.5 mg/kg i.p) in animals pretreated with candesartan, a selective AT1 receptor blocker (3 mg/kg p.o × 5 days), and amphetamine (5 mg/kg i.p) 3 weeks before the challenge.
Increased c-fos immunoreactivity was found in response to the amphetamine challenge in the dorsomedial caudate-putamen and nucleus accumbens, and both responses were blunted by the AT1 receptor blocker pretreatment.
In the infralimbic prefrontal cortex, increased c-fos immunoreactivity was found in response to amphetamine and saline challenge, and both were prevented by the AT1 receptor blocker.
No differences were found neither in ventral tegmental area nor prelimbic cortex between groups.
Our results indicate an important role for brain Ang II in the behavioral and neuronal sensitization induced by amphetamine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Paz, Maria Constanza& Marchese, Natalia Andrea& Cancela, Liliana M.& Bregonzio, Claudia. 2013. Angiotensin II AT1 Receptors Are Involved in Neuronal Activation Induced by Amphetamine in a Two-Injection Protocol. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030637
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Paz, Maria Constanza…[et al.]. Angiotensin II AT1 Receptors Are Involved in Neuronal Activation Induced by Amphetamine in a Two-Injection Protocol. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030637
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Paz, Maria Constanza& Marchese, Natalia Andrea& Cancela, Liliana M.& Bregonzio, Claudia. Angiotensin II AT1 Receptors Are Involved in Neuronal Activation Induced by Amphetamine in a Two-Injection Protocol. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030637
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030637
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر