Cytotoxicity and Genotoxicity Evaluation of Organochalcogens in Human Leucocytes: A Comparative Study between Ebselen, Diphenyl Diselenide, and Diphenyl Ditelluride
المؤلفون المشاركون
da Rocha, João Batista Teixeira
Caeran Bueno, Diones
Meinerz, Daiane Francine
Allebrandt, Josiane
Waczuk, Emily Pansera
dos Santos, Danúbia Bonfanti
Mariano, Douglas Oscar Ceolin
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Organochalcogens, particularly ebselen, have been used in experimental and clinical trials with borderline efficacy.
(PhSe)2 and (PhTe)2 are the simplest of the diaryl dichalcogenides and share with ebselen pharmacological properties.
In view of the concerns with the use of mammals in studies and the great number of new organochalcogens with potential pharmacological properties that have been synthesized, it becomes important to develop screening protocols to select compounds that are worth to be tested in vivo.
This study investigated the possible use of isolated human white cells as a preliminary model to test organochalcogen toxicity.
Human leucocytes were exposed to 5–50 μM of ebselen, (PhSe)2, or (PhTe)2.
All compounds were cytotoxic (Trypan’s Blue exclusion) at the highest concentration tested, and Ebselen was the most toxic.
Ebselen and (PhSe)2 were genotoxic (Comet Assay) only at 50 μM, and (PhTe)2 at 5–50 μM.
Here, the acute cytotoxicity did not correspond with in vivo toxicity of the compounds.
But the genotoxicity was in the same order of the in vivo toxicity to mice.
These results indicate that in vitro genotoxicity in white blood cells should be considered as an early step in the investigation of potential toxicity of organochalcogens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Caeran Bueno, Diones& Meinerz, Daiane Francine& Allebrandt, Josiane& Waczuk, Emily Pansera& dos Santos, Danúbia Bonfanti& Mariano, Douglas Oscar Ceolin…[et al.]. 2013. Cytotoxicity and Genotoxicity Evaluation of Organochalcogens in Human Leucocytes: A Comparative Study between Ebselen, Diphenyl Diselenide, and Diphenyl Ditelluride. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030640
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Caeran Bueno, Diones…[et al.]. Cytotoxicity and Genotoxicity Evaluation of Organochalcogens in Human Leucocytes: A Comparative Study between Ebselen, Diphenyl Diselenide, and Diphenyl Ditelluride. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030640
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Caeran Bueno, Diones& Meinerz, Daiane Francine& Allebrandt, Josiane& Waczuk, Emily Pansera& dos Santos, Danúbia Bonfanti& Mariano, Douglas Oscar Ceolin…[et al.]. Cytotoxicity and Genotoxicity Evaluation of Organochalcogens in Human Leucocytes: A Comparative Study between Ebselen, Diphenyl Diselenide, and Diphenyl Ditelluride. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030640
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030640
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر