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Hippocampal Gene Expression of Deiodinases 2 and 3 and Effects of 3,5-Diiodo-L-Thyronine T2 in Mouse Depression Paradigms
المؤلفون المشاركون
Markova, Natalyia
Chernopiatko, Anton
Schroeter, Careen A.
Malin, Dmitry
Costa-Nunes, João
Strekalova, Tatyana
Steinbusch, H. W. M.
Kubatiev, Aslan
Bachurin, S. O.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-10
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Central thyroid hormone signaling is important in brain function/dysfunction, including affective disorders and depression.
In contrast to 3,3′,5-triiodo-L-thyronine (T3), the role of 3,5-diiodo-L-thyronine (T2), which until recently was considered an inactive metabolite of T3, has not been studied in these pathologies.
However, both T3 and T2 stimulate mitochondrial respiration, a factor counteracting the pathogenesis of depressive disorder, but the cellular origins in the CNS, mechanisms, and kinetics of the cellular action for these two hormones are distinct and independent of each other.
Here, Illumina and RT PCR assays showed that hippocampal gene expression of deiodinases 2 and 3, enzymes involved in thyroid hormone regulation, is increased in resilience to stress-induced depressive syndrome and after antidepressant treatment in mice that might suggest elevated T2 and T3 turnover in these phenotypes.
In a separate experiment, bolus administration of T2 at the doses 750 and 1500 mcg/kg but not 250 mcg/kg in naive mice reduced immobility in a two-day tail suspension test in various settings without changing locomotion or anxiety.
This demonstrates an antidepressant-like effect of T2 that could be exploited clinically.
In a wider context, the current study suggests important central functions of T2, whose biological role only lately is becoming to be elucidated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Markova, Natalyia& Chernopiatko, Anton& Schroeter, Careen A.& Malin, Dmitry& Kubatiev, Aslan& Bachurin, S. O.…[et al.]. 2013. Hippocampal Gene Expression of Deiodinases 2 and 3 and Effects of 3,5-Diiodo-L-Thyronine T2 in Mouse Depression Paradigms. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030665
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Markova, Natalyia…[et al.]. Hippocampal Gene Expression of Deiodinases 2 and 3 and Effects of 3,5-Diiodo-L-Thyronine T2 in Mouse Depression Paradigms. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1030665
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Markova, Natalyia& Chernopiatko, Anton& Schroeter, Careen A.& Malin, Dmitry& Kubatiev, Aslan& Bachurin, S. O.…[et al.]. Hippocampal Gene Expression of Deiodinases 2 and 3 and Effects of 3,5-Diiodo-L-Thyronine T2 in Mouse Depression Paradigms. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030665
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030665
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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