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Lovastatin in Aspergillus terreus: Fermented Rice Straw Extracts Interferes with Methane Production and Gene Expression in Methanobrevibacter smithii
المؤلفون المشاركون
Faseleh Jahromi, Mohammad
Liang, Juan Boo
Chin, James
Mohammad, Rosfarizan
Ho, Yin Wan
Yong Meng, Goh
Shokryazdan, Parisa
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Lovastatin, a natural byproduct of some fungi, is able to inhibit HMG-CoA (3-hydroxy-3methyl glutaryl CoA) reductase.
This is a key enzyme involved in isoprenoid synthesis and essential for cell membrane formation in methanogenic Archaea.
In this paper, experiments were designed to test the hypothesis that lovastatin secreted by Aspergillus terreus in fermented rice straw extracts (FRSE) can inhibit growth and CH4 production in Methanobrevibacter smithii (a test methanogen).
By HPLC analysis, 75% of the total lovastatin in FRSE was in the active hydroxyacid form, and in vitro studies confirmed that this had a stronger effect in reducing both growth and CH4 production in M.
smithii compared to commercial lovastatin.
Transmission electron micrographs revealed distorted morphological divisions of lovastatin- and FRSE-treated M.
smithii cells, supporting its role in blocking normal cell membrane synthesis.
Real-time PCR confirmed that both commercial lovastatin and FRSE increased (P<0.01) the expression of HMG-CoA reductase gene (hmg).
In addition, expressions of other gene transcripts in M.
smithii.
with a key involvement in methanogenesis were also affected.
Experimental confirmation that CH4 production is inhibited by lovastatin in A.
terreus-fermented rice straw paves the way for its evaluation as a feed additive for mitigating CH4 production in ruminants.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Faseleh Jahromi, Mohammad& Liang, Juan Boo& Ho, Yin Wan& Mohammad, Rosfarizan& Yong Meng, Goh& Shokryazdan, Parisa…[et al.]. 2013. Lovastatin in Aspergillus terreus: Fermented Rice Straw Extracts Interferes with Methane Production and Gene Expression in Methanobrevibacter smithii. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030708
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Faseleh Jahromi, Mohammad…[et al.]. Lovastatin in Aspergillus terreus: Fermented Rice Straw Extracts Interferes with Methane Production and Gene Expression in Methanobrevibacter smithii. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030708
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Faseleh Jahromi, Mohammad& Liang, Juan Boo& Ho, Yin Wan& Mohammad, Rosfarizan& Yong Meng, Goh& Shokryazdan, Parisa…[et al.]. Lovastatin in Aspergillus terreus: Fermented Rice Straw Extracts Interferes with Methane Production and Gene Expression in Methanobrevibacter smithii. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030708
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030708
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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