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Cerebral Activation during Von Frey Filament Stimulation in Subjects with Endothelin-1-Induced Mechanical Hyperalgesia: A Functional MRI Study
المؤلفون المشاركون
Vandervliet, Everhard
Deseure, Kristof
Parizel, Paul M.
Hans, G.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Endothelin-1 (ET-1) is an endogenously expressed potent peptide vasoconstrictor.
There is growing evidence that ET-1 plays a role in the pain signaling system and triggers overt nociception in humans.
The underlying neuronal pathways are still a matter of great debate.
In the present study, we applied an intradermal ET-1 sensitization model to induce mechanical hyperalgesia in healthy subjects.
Functional magnetic resonance imaging (fMRI) was used to tease out the cortical regions associated with the processing of ET-1-induced punctate hyperalgesia, as compared to a nonnoxious mechanical stimulation of the contralateral arm.
Von Frey hair testing revealed the presence of increased responsiveness to punctate stimulation in all subjects.
Activational patterns between nonpainful control stimulation and hyperalgesic stimulation were compared.
Two major observations were made: (1) all cortical areas that showed activation during the control stimulation were also present during hyperalgesic stimulation, but in addition, some areas showed bilateral activation only during hyperalgesic stimulation, and (2) some brain areas showed significantly higher signal changes during hyperalgesic stimulation.
Our findings suggest that injection of ET-1 leads to a state of punctate hyperalgesia, which in turn causes the activation of multiple brain regions.
This indicates that ET-1 activates an extended neuronal pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hans, G.& Vandervliet, Everhard& Deseure, Kristof& Parizel, Paul M.. 2013. Cerebral Activation during Von Frey Filament Stimulation in Subjects with Endothelin-1-Induced Mechanical Hyperalgesia: A Functional MRI Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030715
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hans, G.…[et al.]. Cerebral Activation during Von Frey Filament Stimulation in Subjects with Endothelin-1-Induced Mechanical Hyperalgesia: A Functional MRI Study. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030715
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hans, G.& Vandervliet, Everhard& Deseure, Kristof& Parizel, Paul M.. Cerebral Activation during Von Frey Filament Stimulation in Subjects with Endothelin-1-Induced Mechanical Hyperalgesia: A Functional MRI Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030715
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030715
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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