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Preoperative Chemoradiotherapy in Elderly Patients with Locally Advanced Rectal Cancer
المؤلفون المشاركون
Izzo, Luciano
Pugliese, Federico
Izzo, Paolo
Bolognese, Antonio
Tombolini, Vincenzo
De Felice, Francesca
Musio, Daniela
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-12
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate the treatment tolerance and clinical outcomes in patients aged 70 and older with locally advanced rectal carcinoma treated with multimodality approach.
Methods and Materials.
We retrospectively analysed 20 consecutive elderly patients, with histologically proven rectal adenocarcinoma, staged T3-4, and/or node-positive tumour, who received chemoradiotherapy and proceeded to surgical approach.
Performance status score and adult comorbidity evaluation-27 score were calculated, and their influence on treatment tolerance and clinical outcomes was analysed.
Results.
All patients completed programmed chemoradiotherapy treatment.
Gastrointestinal toxicity was the most common acute side effects: proctitis in 70% of patients and diarrhoea in 55%, classified as Grade 3 in 3 patients only.
Radiation dermatitis was reported in 7 patients (35%) and it was graded G3 in one patient.
There was no haematological toxicity.
Eighteen patients out of 20 underwent surgery.
Sphincter preservation was assured in 13 patients.
Comorbidity index was related to higher severe acute toxicity (P=0.015) but no influenced treatment outcomes.
Conclusion.
Treatment tolerance with combined modality is good in elderly patients.
Due to age, no dose reduction for radiation therapy and chemotherapy should be considered.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
De Felice, Francesca& Musio, Daniela& Izzo, Luciano& Pugliese, Federico& Izzo, Paolo& Bolognese, Antonio…[et al.]. 2013. Preoperative Chemoradiotherapy in Elderly Patients with Locally Advanced Rectal Cancer. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030716
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
De Felice, Francesca…[et al.]. Preoperative Chemoradiotherapy in Elderly Patients with Locally Advanced Rectal Cancer. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030716
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
De Felice, Francesca& Musio, Daniela& Izzo, Luciano& Pugliese, Federico& Izzo, Paolo& Bolognese, Antonio…[et al.]. Preoperative Chemoradiotherapy in Elderly Patients with Locally Advanced Rectal Cancer. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030716
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030716
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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