Protective Efficacy of N-(2-Hydroxyphenyl) Acetamide against Adjuvant-Induced Arthritis in Rats
المؤلفون المشاركون
Jawed, Huma
Perveen, Kahkashan
Hanif, Farina
Simjee, Shabana Usman
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Rheumatoid arthritis is a chronic inflammatory joint disease characterized by synovial proliferation and tissue destruction.
Proinflammatory cytokines like interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) play a key role in the disease process and elevate energy expenditure, which further increases the joint pain and stiffness.
To explore the effects of N-(2-hydroxyphenyl) acetamide (NA-2) on the development of arthritis, clinical signs, histopathology of knee joints, nociception analysis, and the serum levels of IL-1β and TNF-α were monitored.
Arthritis was induced by intradermal administration of heat-killed adjuvant Mycobacterium tuberculosis H37Ra in rats.
NA-2 and indomethacin treatments were started in their respective group on the same day when adjuvant was administered.
Experiments were terminated when arthritic score of 4 was observed in arthritic control group.
NA-2 (5 mg/kg) treatment significantly ameliorated the disease severity.
Reduction in body weight and increase in paw oedema were significantly reversed in arthritic animal receiving NA-2.
The nociceptive sensation was also inhibited in the NA-2 treated arthritic rats.
Remission was associated with improved histology and significant decreased expression of serum proinflammatory cytokines (P<0.05 for IL-1β and TNF-α).
Based on our observations, it can be suggested that NA-2 possesses promising anti-arthritic property, and it can be used as a therapeutic agent for arthritis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Perveen, Kahkashan& Hanif, Farina& Jawed, Huma& Simjee, Shabana Usman. 2013. Protective Efficacy of N-(2-Hydroxyphenyl) Acetamide against Adjuvant-Induced Arthritis in Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030747
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Perveen, Kahkashan…[et al.]. Protective Efficacy of N-(2-Hydroxyphenyl) Acetamide against Adjuvant-Induced Arthritis in Rats. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030747
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Perveen, Kahkashan& Hanif, Farina& Jawed, Huma& Simjee, Shabana Usman. Protective Efficacy of N-(2-Hydroxyphenyl) Acetamide against Adjuvant-Induced Arthritis in Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030747
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030747
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر