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Very Small Embryonic-Like Stem Cells: Implications in Reproductive Biology
المؤلفون المشاركون
Parte, Seema
Unni, Sreepoorna
Anand, Sandhya
Bhartiya, Deepa
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The most primitive germ cells in adult mammalian testis are the spermatogonial stem cells (SSCs) whereas primordial follicles (PFs) are considered the fundamental functional unit in ovary.
However, this central dogma has recently been modified with the identification of a novel population of very small embryonic-like stem cells (VSELs) in the adult mammalian gonads.
These stem cells are more primitive to SSCs and are also implicated during postnatal ovarian neo-oogenesis and primordial follicle assembly.
VSELs are pluripotent in nature and characterized by nuclear Oct-4A, cell surface SSEA-4, and other pluripotent markers like Nanog, Sox2, and TERT.
VSELs are considered to be the descendants of epiblast stem cells and possibly the primordial germ cells that persist into adulthood and undergo asymmetric cell division to replenish the gonadal germ cells throughout life.
Elucidation of their role during infertility, endometrial repair, superovulation, and pathogenesis of various reproductive diseases like PCOS, endometriosis, cancer, and so on needs to be addressed.
Hence, a detailed review of current understanding of VSEL biology is pertinent, which will hopefully open up new avenues for research to better understand various reproductive processes and cancers.
It will also be relevant for future regenerative medicine, translational research, and clinical applications in human reproduction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bhartiya, Deepa& Unni, Sreepoorna& Parte, Seema& Anand, Sandhya. 2013. Very Small Embryonic-Like Stem Cells: Implications in Reproductive Biology. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030784
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bhartiya, Deepa…[et al.]. Very Small Embryonic-Like Stem Cells: Implications in Reproductive Biology. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030784
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bhartiya, Deepa& Unni, Sreepoorna& Parte, Seema& Anand, Sandhya. Very Small Embryonic-Like Stem Cells: Implications in Reproductive Biology. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030784
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030784
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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