Moving toward Personalized Medicine in the Methadone Maintenance Treatment Program: A Pilot Study on the Evaluation of Treatment Responses in Taiwan
المؤلفون المشاركون
Lee, Hsin-Ya
Li, Jih-Heng
Sheu, Yuh-Ling
Tang, Hsin-Pei
Tang, Tze-Chun
Yeh, Yi-Chun
Wang, Shing-Yaw
Liu, Ray-H.
Chang, Wei Chiao
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This pilot study simultaneously evaluated the effects of various factors, including genetic variations of CYP2B6, CYP2C19, and ABCB1, demographic characteristics, disease states, methadone-drug interactions (MDIs), and poly-substance use, on the treatment responses among non-HIV patients in the methadone maintenance treatment program (MMTP) in Taiwan.
A total of 178 patients were recruited from two major hospitals that provided MMTP services in southern Taiwan, and information regarding concomitant medications and diseases was acquired from the National Health Insurance (NHI) program.
The results demonstrated that the methadone maintenance dose, CYP2B6 785G allele, and ABCB1 2677T allele have positive effects on the methadone plasma concentration.
In contrast, patients with HCV coinfection, alcohol problems, and psychiatric diseases may have a negative response to treatment.
Thus, a comprehensive evaluation of treatment responses in the MMTP should include not only genetic polymorphisms in methadone metabolism and transporter proteins, but also concomitant diseases, MDIs, and poly-substance use.
The results also suggest that personalized medicine may be indispensable for a better outcome of the MMTP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Hsin-Ya& Li, Jih-Heng& Sheu, Yuh-Ling& Tang, Hsin-Pei& Chang, Wei Chiao& Tang, Tze-Chun…[et al.]. 2013. Moving toward Personalized Medicine in the Methadone Maintenance Treatment Program: A Pilot Study on the Evaluation of Treatment Responses in Taiwan. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Hsin-Ya…[et al.]. Moving toward Personalized Medicine in the Methadone Maintenance Treatment Program: A Pilot Study on the Evaluation of Treatment Responses in Taiwan. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Hsin-Ya& Li, Jih-Heng& Sheu, Yuh-Ling& Tang, Hsin-Pei& Chang, Wei Chiao& Tang, Tze-Chun…[et al.]. Moving toward Personalized Medicine in the Methadone Maintenance Treatment Program: A Pilot Study on the Evaluation of Treatment Responses in Taiwan. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030864
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر