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Environmental Lead Exposure Accelerates Progressive Diabetic Nephropathy in Type II Diabetic Patients
المؤلفون المشاركون
Yen, Tzung-Hai
Huang, Wen-Hung
Lin, Ja-Liang
Chen, Kuan-Hsing
Lin, Ja-Liang
Hsu, Ching-Wei
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Whether environmental lead exposure has a long-term effect on progressive diabetic nephropathy in type II diabetic patients remains unclear.
A total of 107 type II diabetic patients with stage 3 diabetic nephropathy (estimated glomerular filtration rate (eGFR) range, 30–60 mL/min/1.73 m2) with normal body lead burden (BLB) (<600 μg/72 hr in EDTA mobilization tests) and no history of exposure to lead were prospectively followed for 2 years.
Patients were divided into high-normal BLB (>80 μg) and low-normal BLB (<80 μg) groups.
The primary outcome was a 2-fold increase in the initial creatinine levels, long-term dialysis, or death.
The secondary outcome was a change in eGFR over time.
Forty-five patients reached the primary outcome within 2 years.
Although there were no differences in baseline data and renal function, progressive nephropathy was slower in the low-normal BLB group than that in the high-normal BLB group.
During the study period, we demonstrated that each 100 μg increment in BLB and each 10 μg increment in blood lead levels could decrease GFR by 2.2 mL/min/1.72 m2 and 3.0 mL/min/1.72 m2 (P=0.005), respectively, as estimated by generalized equations.
Moreover, BLB was associated with increased risk of achieving primary outcome.
Environmental exposure to lead may have a long-term effect on progressive diabetic nephropathy in type II diabetic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Wen-Hung& Lin, Ja-Liang& Lin, Ja-Liang& Hsu, Ching-Wei& Chen, Kuan-Hsing& Yen, Tzung-Hai. 2013. Environmental Lead Exposure Accelerates Progressive Diabetic Nephropathy in Type II Diabetic Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Wen-Hung…[et al.]. Environmental Lead Exposure Accelerates Progressive Diabetic Nephropathy in Type II Diabetic Patients. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Wen-Hung& Lin, Ja-Liang& Lin, Ja-Liang& Hsu, Ching-Wei& Chen, Kuan-Hsing& Yen, Tzung-Hai. Environmental Lead Exposure Accelerates Progressive Diabetic Nephropathy in Type II Diabetic Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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