Heparanase Localization during Palatogenesis in Mice
المؤلفون المشاركون
Otsuki, Yoshinori
Hirata, Azumi
Katayama, Kentaro
Tsuji, Takehito
Natsume, Nagato
Sugahara, Toshio
Koga, Yuichi
Takano, Kazufumi
Nakamura, Hiroaki
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Palatogenesis is directed by epithelial-mesenchymal interactions and results partly from remodeling of the extracellular matrix (ECM) of the palatal shelves.
Here, we assessed heparanase distribution in developing mouse palates.
No heparanase was observed in the vertically oriented palatal shelves in early stages of palate formation.
As palate formation progressed, the palatal shelves were reorganized and arranged horizontally above the tongue, and heparanase localized to the epithelial cells of these shelves.
When the palatal bilateral shelves first made contact, the heparanase localized to epithelial cells at the tips of shelves.
Later in fusing palatal shelves, the cells of the medial epithelial seam (MES) were labeled with intense heparanase signal.
In contrast, the basement membrane heparan sulfate (HS) was scarcely observed in the palatal shelves in contact.
Moreover, perlecan labeling was sparse in the basement membrane of the MES, on which laminin and type IV collagen were observed.
Moreover, we assessed the distribution of matrix metalloproteinase- (MMP-) 9, MMP-2, and MMP-3 in developing mouse palates and these MMPs were observed in the MES.
Our findings indicated that heparanase was important for palate formation because it mediated degradation of the ECM of palatal shelves.
Heparanase may, in concert with other proteases, participate in the regression of the MES.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hirata, Azumi& Katayama, Kentaro& Tsuji, Takehito& Natsume, Nagato& Sugahara, Toshio& Koga, Yuichi…[et al.]. 2013. Heparanase Localization during Palatogenesis in Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030887
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hirata, Azumi…[et al.]. Heparanase Localization during Palatogenesis in Mice. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030887
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hirata, Azumi& Katayama, Kentaro& Tsuji, Takehito& Natsume, Nagato& Sugahara, Toshio& Koga, Yuichi…[et al.]. Heparanase Localization during Palatogenesis in Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030887
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030887
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر