Chromosome Instability and Oxidative Stress Markers in Patients with Ataxia Telangiectasia and Their Parents

المؤلفون المشاركون

Prá, Daniel
Bitelo Ludwig, Luciane
Valiati, Victor Hugo
Palazzo, Roberta Passos
Jardim, Laura Bannach
da Rosa, Darlan Pase
Bona, Silvia
Rodrigues, Graziela
Maluf, Sharbel Weidner
Marroni, Norma Anair Possa

المصدر

BioMed Research International

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-07-09

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Ataxia telangiectasia (AT) is a rare neurodegenerative disorder, inherited in an autosomal recessive manner.

Total blood samples were collected from 20 patients with AT, 13 parents of patients, and 17 healthy volunteers.

This study aimed at evaluating the frequency of chromosomal breaks in spontaneous cultures, induced by bleomycin and ionizing radiation, and further evaluated the rates of oxidative stress in AT patients and in their parents, compared to a control group.

Three cell cultures were performed to each individual: the first culture did not receive induction to chromosomal instability, the second was exposed to bleomycin, and the last culture was exposed to ionizing radiation.

To evaluate the rates of oxidative stress, the markers superoxide dismutase (SOD), catalase (CAT), and thiobarbituric acid (TBARS) were utilized.

Significant differences were observed between the three kinds of culture treatments (spontaneous, bleomycin, and radiation induced) and the breaks and chromosomal aberrations in the different groups.

The oxidative stress showed no significant differences between the markers.

This study showed that techniques of chromosomal instability after the induction of ionizing radiation and bleomycin are efficient in the identification of syndrome patients, with the ionizing radiation being the most effective.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Bitelo Ludwig, Luciane& Valiati, Victor Hugo& Palazzo, Roberta Passos& Jardim, Laura Bannach& da Rosa, Darlan Pase& Bona, Silvia…[et al.]. 2013. Chromosome Instability and Oxidative Stress Markers in Patients with Ataxia Telangiectasia and Their Parents. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030890

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Bitelo Ludwig, Luciane…[et al.]. Chromosome Instability and Oxidative Stress Markers in Patients with Ataxia Telangiectasia and Their Parents. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030890

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Bitelo Ludwig, Luciane& Valiati, Victor Hugo& Palazzo, Roberta Passos& Jardim, Laura Bannach& da Rosa, Darlan Pase& Bona, Silvia…[et al.]. Chromosome Instability and Oxidative Stress Markers in Patients with Ataxia Telangiectasia and Their Parents. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030890

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1030890