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In Vitro Manganese Exposure Disrupts MAPK Signaling Pathways in Striatal and Hippocampal Slices from Immature Rats
المؤلفون المشاركون
Aschner, Michael
Walz, Roger
Peres, Tanara Vieira
Pedro, Daniela Zótico
de Cordova, Fabiano Mendes
Lopes, Mark William
Gonçalves, Filipe Marques
Mendes-de-Aguiar, Cláudia Beatriz Nedel
Leal, Rodrigo Bainy
Farina, Marcelo
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The molecular mechanisms mediating manganese (Mn)-induced neurotoxicity, particularly in the immature central nervous system, have yet to be completely understood.
In this study, we investigated whether mitogen-activated protein kinases (MAPKs) and tyrosine hydroxylase (TH) could represent potential targets of Mn in striatal and hippocampal slices obtained from immature rats (14 days old).
The aim of this study was to evaluate if the MAPK pathways are modulated after subtoxic Mn exposure, which do not significantly affect cell viability.
The concentrations of manganese chloride (MnCl2; 10–1,000 μM) caused no change in cell viability in slices exposed for 3 or 6 hours.
However, Mn exposure significantly increased extracellular signal-regulated kinase (ERK) 1/2, as well as c-Jun N-terminal kinase (JNK) 1/2/3 phosphorylation at both 3 and 6 hours incubations, in both brain structures.
Furthermore, Mn exposure did not change the total content or phosphorylation of TH at the serine 40 site in striatal slices.
Thus, Mn at concentrations that do not disrupt cell viability causes activation of MAPKs (ERK1/2 and JNK1/2/3) in immature hippocampal and striatal slices.
These findings suggest that altered intracellular MAPKs signaling pathways may represent an early event concerning the effects of Mn in the immature brain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peres, Tanara Vieira& Pedro, Daniela Zótico& de Cordova, Fabiano Mendes& Lopes, Mark William& Gonçalves, Filipe Marques& Mendes-de-Aguiar, Cláudia Beatriz Nedel…[et al.]. 2013. In Vitro Manganese Exposure Disrupts MAPK Signaling Pathways in Striatal and Hippocampal Slices from Immature Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030898
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peres, Tanara Vieira…[et al.]. In Vitro Manganese Exposure Disrupts MAPK Signaling Pathways in Striatal and Hippocampal Slices from Immature Rats. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030898
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peres, Tanara Vieira& Pedro, Daniela Zótico& de Cordova, Fabiano Mendes& Lopes, Mark William& Gonçalves, Filipe Marques& Mendes-de-Aguiar, Cláudia Beatriz Nedel…[et al.]. In Vitro Manganese Exposure Disrupts MAPK Signaling Pathways in Striatal and Hippocampal Slices from Immature Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030898
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030898
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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