![](/images/graphics-bg.png)
Anthelmintic Effects of Alkylated Diamines and Amino Alcohols against Schistosoma mansoni
المؤلفون المشاركون
Rodrigues, Vanderlei
da Silva Filho, Ademar Alves
Fernandes, Fábio de Souza
Rezende Júnior, Celso O.
Fernandes, Tayrine Silva
da Silveira, Lígia Souza
Rezende, Carlos A. M.
De Almeida, Mauro V.
de Paula, Renato G.
Couri, Mara R. C.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Polyamines are substances involved in many aspects of cell growth, division, and differentiation.
Because of the metabolic differences between host cells and parasite cells, polyamine metabolism has been considered as a potential target for the chemotherapy of parasitic diseases.
The aim of this work was to evaluate the schistosomicidal activity of different N-alkylated diamines (3a–3h), amino alcohols (4a–4d), and glycosylated amino alcohols (10a–10d).
Compounds were prepared by synthetic methods and submitted to in vitro evaluation against adult worms of Schistosoma mansoni.
At 100 μM, 3b, 3e, and 3h as well as 4a, 4b, 4d, 10a, 10b, and 10d resulted in 100% mortality of adult schistosomes.
Compound 3d (12.5 to 100 μM) caused the death of 100% of both male and female adult schistosomes, while 3f (12.5 to 100 μM) resulted in 100% mortality of only male adult worms, whereas no mortality in female worms was observed.
Compounds 3d and 3f were also able to reduce viability and decrease production of developed eggs in comparison with the negative control group.
Diamines 3d and 3f may represent useful lead compounds for further optimization in order to develop new schistosomicidal agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fernandes, Fábio de Souza& Rezende Júnior, Celso O.& Fernandes, Tayrine Silva& da Silveira, Lígia Souza& Rezende, Carlos A. M.& De Almeida, Mauro V.…[et al.]. 2013. Anthelmintic Effects of Alkylated Diamines and Amino Alcohols against Schistosoma mansoni. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030906
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fernandes, Fábio de Souza…[et al.]. Anthelmintic Effects of Alkylated Diamines and Amino Alcohols against Schistosoma mansoni. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030906
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fernandes, Fábio de Souza& Rezende Júnior, Celso O.& Fernandes, Tayrine Silva& da Silveira, Lígia Souza& Rezende, Carlos A. M.& De Almeida, Mauro V.…[et al.]. Anthelmintic Effects of Alkylated Diamines and Amino Alcohols against Schistosoma mansoni. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030906
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030906
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)