Antiatherosclerotic Potential of Clopidogrel: Antioxidant and Anti-Inflammatory Approaches
المؤلفون المشاركون
Mohammad, Bassim I.
Sahib, Hussam H.
Ajeena, Ihsan M.
Hadi, Najah R.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Atherosclerosis is characterized by endothelial dysfunction, vascular inflammation, and the buildup of lipids, cholesterol, calcium, and cellular debris within the intima of the walls of large and medium size arteries.
Objective.
To evaluate the effect of clopidogrel on atherosclerosis progression.
Materials and Methods.
A total of 28 local domestic rabbits were assigned to four groups: normal control, atherogenic control, vehicle control, and clopidogrel treated.
Serum triglycerides, total cholesterol, HDL-C, plasma high sensitive C-reactive protein (hsCRP), plasma malondialdehyde (MDA), and plasma reduced glutathione (GSH) were measured at the end of the experiment.
Immunohistochemical of aortic atherosclerotic changes were also performed.
Results.
There was no statistically significant difference between atherogenic control group and vehicle group.
Levels of lipid profile, atherogenic index, hsCRP, and MDA are increased while GSH levels were decreased in animals on atherogenic diet.
Immunohistochemical analysis showed that aortic expressions of VCAM-1, MCP-1, TNF-α, and IL-17A were significantly increased in atherogenic control group.
Histopathologic finding showed that animals on atherogenic diet have significant atherosclerotic lesion.
Compared to atherogenic control group clopidogrel do not have significant effect on lipid profile.
Clopidogrel significantly reduces hsCRP and MDA levels and increases GSH level.
Furthermore, clopidogrel treatment significantly reduced aortic expressions parameters and the histopathologic examination of the aortic arch showed a significant reduction of atherosclerotic lesion.
Conclusions.
This study outlines how clopidogrel reduces lipid peroxidation, systemic inflammation, and aortic expression of inflammatory markers and hence reduces the progression of atherosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hadi, Najah R.& Mohammad, Bassim I.& Ajeena, Ihsan M.& Sahib, Hussam H.. 2013. Antiatherosclerotic Potential of Clopidogrel: Antioxidant and Anti-Inflammatory Approaches. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030917
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hadi, Najah R.…[et al.]. Antiatherosclerotic Potential of Clopidogrel: Antioxidant and Anti-Inflammatory Approaches. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030917
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hadi, Najah R.& Mohammad, Bassim I.& Ajeena, Ihsan M.& Sahib, Hussam H.. Antiatherosclerotic Potential of Clopidogrel: Antioxidant and Anti-Inflammatory Approaches. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030917
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030917
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر