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Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model
المؤلفون المشاركون
Saegusa, Yayoi
Yamada, Chihiro
Nakagawa, Koji
Ohnishi, Shunsuke
Muto, Shuichi
Sakamoto, Naoya
Hattori, Tomohisa
Sadakane, C.
Nahata, Miwa
Takeda, Hiroshi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We investigated the effects of rikkunshito (RKT), a ghrelin signal enhancer, on the decrease in food intake after exposure to novelty stress in mice.
RKT administration (500 mg/kg, per os) improved the decrease in 6 h cumulative food intake.
In control mice, the plasma acylated ghrelin levels significantly increased by 24 h fasting.
In contrast, the acylated ghrelin levels did not increase by fasting in mice exposed to the novelty stress.
RKT administration to the novelty stress mice showed a significant increase in the acylated ghrelin levels compared with that in the distilled-water-treated control mice.
Food intake after administering serotonin 2B (5-HT2B) receptor antagonists was evaluated to clarify the role of 5-HT2B receptor activation in the decrease in feeding behavior after novelty stress.
SB215505 and SB204741, 5-HT2B receptor antagonists, significantly improved the decrease in food intake after exposure to novelty stress.
A component of RKT, isoliquiritigenin, prevented the decrease in 6 h cumulative food intake.
Isoliquiritigenin showed 5-HT2B receptor antagonistic activity in vitro.
In conclusion, the results suggested that RKT improves the decrease in food intake after novelty stress probably via 5-HT2B receptor antagonism of isoliquiritigenin contained in RKT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yamada, Chihiro& Saegusa, Yayoi& Nakagawa, Koji& Ohnishi, Shunsuke& Muto, Shuichi& Nahata, Miwa…[et al.]. 2013. Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030921
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yamada, Chihiro…[et al.]. Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030921
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yamada, Chihiro& Saegusa, Yayoi& Nakagawa, Koji& Ohnishi, Shunsuke& Muto, Shuichi& Nahata, Miwa…[et al.]. Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030921
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030921
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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