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Curcumin Inhibits Tumor Growth and Angiogenesis in an Orthotopic Mouse Model of Human Pancreatic Cancer
المؤلفون المشاركون
Bimonte, Sabrina
Barbieri, Antonio
Palma, Giuseppe
Arra, Claudio
Luciano, Antonio
Rea, Domenica
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues forming the pancreas.
The best chemotherapeutic agent used to treat pancreatic cancer is the gemcitabine.
However, gemcitabine treatment is associated with many side effects.
Thus novel strategies involving less toxic agents for treatment of pancreatic cancer are necessary.
Curcumin is one such agent that inhibits the proliferation and angiogenesis of a wide variety of tumor cells, through the modulation of many cell signalling pathways.
In this study, we investigated whether curcumin plays antitumor effects in MIA PaCa-2 cells.
In vitro studies showed that curcumin inhibits the proliferation and enhances apoptosis of MIA PaCa-2 cells.
To test whether the antitumor activity of curcumin is also observed in vivo, we generated an orthotopic mouse model of pancreatic cancer by injection of MIA PaCa-2 cells in nude mice.
We placed mice on diet containing curcumin at 0.6% for 6 weeks.
In these treated mice tumors were smaller with respect to controls and showed a downregulation of the transcription nuclear factor NF-κB and NF-κB-regulated gene products.
Overall, our data indicate that curcumin has a great potential in treatment of human pancreatic cancer through the modulation of NF-κB pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bimonte, Sabrina& Barbieri, Antonio& Palma, Giuseppe& Luciano, Antonio& Rea, Domenica& Arra, Claudio. 2013. Curcumin Inhibits Tumor Growth and Angiogenesis in an Orthotopic Mouse Model of Human Pancreatic Cancer. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030945
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bimonte, Sabrina…[et al.]. Curcumin Inhibits Tumor Growth and Angiogenesis in an Orthotopic Mouse Model of Human Pancreatic Cancer. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030945
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bimonte, Sabrina& Barbieri, Antonio& Palma, Giuseppe& Luciano, Antonio& Rea, Domenica& Arra, Claudio. Curcumin Inhibits Tumor Growth and Angiogenesis in an Orthotopic Mouse Model of Human Pancreatic Cancer. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030945
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030945
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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