No Association of IFNG+874TA SNP and NOS2A-954GC SNP Variants with Nitric Oxide Radical Serum Levels or Susceptibility to Tuberculosis in a Brazilian Population Subset

الملخص EN

Tuberculosis (TB) is one of the most common infectious diseases in the world.

Mycobacterium tuberculosis infection leads to pulmonary active disease in approximately 5–10% of exposed individuals.

Both bacteria- and host-related characteristics influence latent infection and disease.

Host genetic predisposition to develop TB may involve multiple genes and their polymorphisms.

It was reported previously that interferon gamma (IFN-γ) and nitric oxide synthase 2 (NOS2) are expressed on alveolar macrophages from TB patients and are responsible for bacilli control; thus, we aimed this study at genotyping single nucleotide polymorphisms IFNG+874T/A SNP and NOS2A-954G/C SNP to estimate their role on TB susceptibility and determine whether these polymorphisms influence serum nitrite and NOx- production.

This case-control study enrolled 172 TB patients and 179 healthy controls.

Neither polymorphism was associated with susceptibility to TB.

NOS2A-954G/C SNP was not associated with serum levels of nitrite and NOx-.

These results indicate that variants of IFNG+874T/A SNP and NOS2A-954G/C SNP do not influence TB susceptibility or the secretion of nitric oxide radicals in the study population.