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Isolation, Characterization, and Transduction of Endometrial Decidual Tissue Multipotent Mesenchymal StromalStem Cells from Menstrual Blood
المؤلفون المشاركون
Pietro, Loschi
Dominici, Massimo
Rossignoli, Filippo
Caselli, Anna
Grisendi, Giulia
Piccinno, Serena
Burns, Jorge S.
Murgia, Alba
Veronesi, Elena
Masini, Cristina
Conte, Pierfranco
Paolucci, Paolo
Horwiz, Edwin M.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Mesenchymal stromal/stem cells (MSCs) reveal progenitor cells-like features including proliferation and differentiation capacities.
One of the most historically recognized sources of MSC has been the bone marrow, while other sources recently include adipose tissue, teeth, bone, muscle, placenta, liver, pancreas, umbilical cord, and cord blood.
Frequently, progenitor isolation requires traumatic procedures that are poorly feasible and associated with patient discomfort.
In the attempt to identify a more approachable MSC source, we focused on endometrial decidual tissue (EDT) found within menstrual blood.
Based also on recent literature findings, we hypothesized that EDT may contain heterogeneous populations including some having MSC-like features.
Thus, we here sought to isolate EDT-MSC processing menstrual samples from multiple donors.
Cytofluorimetric analyses revealed that resulting adherent cells were expressing mesenchymal surface markers, including CD56, CD73, CD90, CD105 and CD146, and pluripotency markers such as SSEA-4.
Moreover, EDT-MSC showed a robust clonogenic potential and could be largely expanded in vitro as fibroblastoid elements.
In addition, differentiation assays drove these cells towards osteogenic, adipogenic, and chondrogenic lineages.
Finally, for the first time, we were able to gene modify these progenitors by a retroviral vector carrying the green fluorescent protein.
From these data, we suggest that EDT-MSC could represent a new promising tool having potential within cell and gene therapy applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rossignoli, Filippo& Caselli, Anna& Grisendi, Giulia& Piccinno, Serena& Burns, Jorge S.& Murgia, Alba…[et al.]. 2013. Isolation, Characterization, and Transduction of Endometrial Decidual Tissue Multipotent Mesenchymal StromalStem Cells from Menstrual Blood. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1031061
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rossignoli, Filippo…[et al.]. Isolation, Characterization, and Transduction of Endometrial Decidual Tissue Multipotent Mesenchymal StromalStem Cells from Menstrual Blood. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1031061
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rossignoli, Filippo& Caselli, Anna& Grisendi, Giulia& Piccinno, Serena& Burns, Jorge S.& Murgia, Alba…[et al.]. Isolation, Characterization, and Transduction of Endometrial Decidual Tissue Multipotent Mesenchymal StromalStem Cells from Menstrual Blood. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1031061
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031061
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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