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Detergent-Enzymatic Decellularization of Swine Blood Vessels: Insight on Mechanical Properties for Vascular Tissue Engineering
المؤلفون المشاركون
Zonta, Sandro
Stefani, Ilaria
Dominioni, Tommaso
Pellegata, Alessandro F.
Mantero, Sara
Maestroni, Anna
Zerbini, Gianpaolo
Asnaghi, M. Adelaide
Maestroni, Silvia
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Small caliber vessels substitutes still remain an unmet clinical need; few autologous substitutes are available, while synthetic grafts show insufficient patency in the long term.
Decellularization is the complete removal of all cellular and nuclear matters from a tissue while leaving a preserved extracellular matrix representing a promising tool for the generation of acellular scaffolds for tissue engineering, already used for various tissues with positive outcomes.
The aim of this work is to investigate the effect of a detergent-enzymatic decellularization protocol on swine arteries in terms of cell removal, extracellular matrix preservation, and mechanical properties.
Furthermore, the effect of storage at −80°C on the mechanical properties of the tissue is evaluated.
Swine arteries were harvested, frozen, and decellularized; histological analysis revealed complete cell removal and preserved extracellular matrix.
Furthermore, the residual DNA content in decellularized tissues was far low compared to native one.
Mechanical testings were performed on native, defrozen, and decellularized tissues; no statistically significant differences were reported for Young’s modulus, ultimate stress, compliance, burst pressure, and suture retention strength, while ultimate strain and stress relaxation of decellularized vessels were significantly different from the native ones.
Considering the overall results, the process was confirmed to be suitable for the generation of acellular scaffolds for vascular tissue engineering.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pellegata, Alessandro F.& Asnaghi, M. Adelaide& Stefani, Ilaria& Maestroni, Anna& Maestroni, Silvia& Dominioni, Tommaso…[et al.]. 2013. Detergent-Enzymatic Decellularization of Swine Blood Vessels: Insight on Mechanical Properties for Vascular Tissue Engineering. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031092
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pellegata, Alessandro F.…[et al.]. Detergent-Enzymatic Decellularization of Swine Blood Vessels: Insight on Mechanical Properties for Vascular Tissue Engineering. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1031092
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pellegata, Alessandro F.& Asnaghi, M. Adelaide& Stefani, Ilaria& Maestroni, Anna& Maestroni, Silvia& Dominioni, Tommaso…[et al.]. Detergent-Enzymatic Decellularization of Swine Blood Vessels: Insight on Mechanical Properties for Vascular Tissue Engineering. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031092
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031092
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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