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Green Tea Polyphenol Epigallocatechin-3-Gallate Enhance Glycogen Synthesis and Inhibit Lipogenesis in Hepatocytes
المؤلفون المشاركون
Xiao, Linda
Kim, Jane J. Y.
Sun, Ya-Li
Qu, Xianqin
Tan, Yi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The beneficial effects of green tea polyphenols (GTP) against metabolic syndrome and type 2 diabetes by suppressing appetite and nutrient absorption have been well reported.
However the direct effects and mechanisms of GTP on glucose and lipid metabolism remain to be elucidated.
Since the liver is an important organ involved in glucose and lipid metabolism, we examined the effects and mechanisms of GTP on glycogen synthesis and lipogenesis in HepG2 cells.
Concentrations of GTP containing 68% naturally occurring (−)-epigallocatechin-3-gallate (EGCG) were incubated in HepG2 cells with high glucose (30 mM) under 100 nM of insulin stimulation for 24 h.
GTP enhanced glycogen synthesis in a dose-dependent manner.
10 μM of EGCG significantly increased glycogen synthesis by 2fold (P<0.05) compared with insulin alone.
Western blotting revealed that phosphorylation of Ser9 glycogen synthase kinase 3β and Ser641 glycogen synthase was significantly increased in GTP-treated HepG2 cells compared with nontreated cells.
10 μM of EGCG also significantly inhibited lipogenesis (P<0.01).
We further demonstrated that this mechanism involves enhanced expression of phosphorylated AMP-activated protein kinase α and acetyl-CoA carboxylase in HepG2 cells.
Our results showed that GTP is capable of enhancing insulin-mediated glucose and lipid metabolism by regulating enzymes involved in glycogen synthesis and lipogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Jane J. Y.& Tan, Yi& Xiao, Linda& Sun, Ya-Li& Qu, Xianqin. 2013. Green Tea Polyphenol Epigallocatechin-3-Gallate Enhance Glycogen Synthesis and Inhibit Lipogenesis in Hepatocytes. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031095
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Jane J. Y.…[et al.]. Green Tea Polyphenol Epigallocatechin-3-Gallate Enhance Glycogen Synthesis and Inhibit Lipogenesis in Hepatocytes. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1031095
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Jane J. Y.& Tan, Yi& Xiao, Linda& Sun, Ya-Li& Qu, Xianqin. Green Tea Polyphenol Epigallocatechin-3-Gallate Enhance Glycogen Synthesis and Inhibit Lipogenesis in Hepatocytes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031095
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031095
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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