DPYD, TYMS, TYMP, TK1, and TK2 Genetic Expressions as Response Markers in Locally Advanced Rectal Cancer Patients Treated with Fluoropyrimidine-Based Chemoradiotherapy
المؤلفون المشاركون
Wu, Chan-Han
Chung, Fu-Yen
Huang, Ching-Wen
Lin, Shiu-Ru
Wang, Jaw-Yuan
Huang, Chun-Ming
Tsai, Hsiang-Lin
Huang, Ming-Yii
Chen, Chin-Fan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This study is to investigate multiple chemotherapeutic agent- and radiation-related genetic biomarkers in locally advanced rectal cancer (LARC) patients following fluoropyrimidine-based concurrent chemoradiotherapy (CCRT) for response prediction.
We initially selected 6 fluoropyrimidine metabolism-related genes (DPYD, ORPT, TYMS, TYMP, TK1, and TK2) and 3 radiotherapy response-related genes (GLUT1, HIF-1α, and HIF-2α) as targets for gene expression identification in 60 LARC cancer specimens.
Subsequently, a high-sensitivity weighted enzymatic chip array was designed and constructed to predict responses following CCRT.
After CCRT, 39 of 60 (65%) LARC patients were classified as responders (pathological tumor regression grade 2~4).
Using a panel of multiple genetic biomarkers (chip), including DPYD, TYMS, TYMP, TK1, and TK2, at a cutoff value for 3 positive genes, a sensitivity of 89.7% and a specificity of 81% were obtained (AUC: 0.915; 95% CI: 0.840–0.991).
Negative chip results were significantly correlated to poor CCRT responses (TRG 0-1) (P=0.014, hazard ratio: 22.704, 95% CI: 3.055–235.448 in multivariate analysis).
Disease-free survival analysis showed significantly better survival rate in patients with positive chip results (P=0.0001).
We suggest that a chip including DPYD, TYMS, TYMP, TK1, and TK2 genes is a potential tool to predict response in LARC following fluoropyrimidine-based CCRT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Ming-Yii& Wu, Chan-Han& Huang, Chun-Ming& Chung, Fu-Yen& Huang, Ching-Wen& Tsai, Hsiang-Lin…[et al.]. 2013. DPYD, TYMS, TYMP, TK1, and TK2 Genetic Expressions as Response Markers in Locally Advanced Rectal Cancer Patients Treated with Fluoropyrimidine-Based Chemoradiotherapy. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031114
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Ming-Yii…[et al.]. DPYD, TYMS, TYMP, TK1, and TK2 Genetic Expressions as Response Markers in Locally Advanced Rectal Cancer Patients Treated with Fluoropyrimidine-Based Chemoradiotherapy. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1031114
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Ming-Yii& Wu, Chan-Han& Huang, Chun-Ming& Chung, Fu-Yen& Huang, Ching-Wen& Tsai, Hsiang-Lin…[et al.]. DPYD, TYMS, TYMP, TK1, and TK2 Genetic Expressions as Response Markers in Locally Advanced Rectal Cancer Patients Treated with Fluoropyrimidine-Based Chemoradiotherapy. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031114
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031114
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر