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Regulation of Tight Junctions in Upper Airway Epithelium
المؤلفون المشاركون
Fujii, Nobuhiro
Kojima, Takashi
Tsutsumi, Hiroyuki
Go, Mitsuru
Takano, Ken-ichi
Kurose, Makoto
Ohkuni, Tsuyoshi
Koizumi, Jun-ichi
Kamekura, Ryuta
Ogasawara, Noriko
Masaki, Tomoyuki
Fuchimoto, Jun
Obata, Kazufumi
Hirakawa, Satoshi
Nomura, Kazuaki
Keira, Takashi
Miyata, Ryou
Himi, Tetsuo
Sawada, Norimasa
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The mucosal barrier of the upper respiratory tract including the nasal cavity, which is the first site of exposure to inhaled antigens, plays an important role in host defense in terms of innate immunity and is regulated in large part by tight junctions of epithelial cells.
Tight junction molecules are expressed in both M cells and dendritic cells as well as epithelial cells of upper airway.
Various antigens are sampled, transported, and released to lymphocytes through the cells in nasal mucosa while they maintain the integrity of the barrier.
Expression of tight junction molecules and the barrier function in normal human nasal epithelial cells (HNECs) are affected by various stimuli including growth factor, TLR ligand, and cytokine.
In addition, epithelial-derived thymic stromal lymphopoietin (TSLP), which is a master switch for allergic inflammatory diseases including allergic rhinitis, enhances the barrier function together with an increase of tight junction molecules in HNECs.
Furthermore, respiratory syncytial virus infection in HNECs in vitro induces expression of tight junction molecules and the barrier function together with proinflammatory cytokine release.
This paper summarizes the recent progress in our understanding of the regulation of tight junctions in the upper airway epithelium under normal, allergic, and RSV-infected conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kojima, Takashi& Go, Mitsuru& Takano, Ken-ichi& Kurose, Makoto& Ohkuni, Tsuyoshi& Koizumi, Jun-ichi…[et al.]. 2012. Regulation of Tight Junctions in Upper Airway Epithelium. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1031134
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kojima, Takashi…[et al.]. Regulation of Tight Junctions in Upper Airway Epithelium. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1031134
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kojima, Takashi& Go, Mitsuru& Takano, Ken-ichi& Kurose, Makoto& Ohkuni, Tsuyoshi& Koizumi, Jun-ichi…[et al.]. Regulation of Tight Junctions in Upper Airway Epithelium. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1031134
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031134
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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