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Role of HLA, KIR, MICA, and Cytokines Genes in Leprosy
المؤلفون المشاركون
Visentainer, Jeane Eliete Laguila
Ayo, Christiane Maria
Jarduli, Luciana Ribeiro
Sell, Ana Maria
Reis, Pâmela Guimarães
Sippert, Emília Ângela
Alves, Hugo Vicentin
Mazini, Priscila Saamara
Teixeira, Jorge Juarez Vieira
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-08
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Many genes including HLA, KIR, and MICA genes, as well as polymorphisms in cytokines have been investigated for their role in infectious disease.
HLA alleles may influence not only susceptibility or resistance to leprosy, but also the course of the disease.
Some combinations of HLA and KIR may result in negative as well as positive interactions between NK cells and infected host cells with M.
leprae, resulting in activation or inhibition of NK cells and, consequently, in death of bacillus.
In addition, studies have demonstrated the influence of MICA genes in the pathogenesis of leprosy.
Specifically, they may play a role in the interaction between NK cells and infected cells.
Finally, pro- and anti-inflammatory cytokines have been influencing the clinical course of leprosy.
Data from a wide variety of sources support the existence of genetic factors influencing the leprosy pathogenesis.
These sources include twin studies, segregation analyses, family-based linkage and association studies, candidate gene association studies, and, most recently, genome-wide association studies (GWAS).
The purpose of this brief review was to highlight the importance of some immune response genes and their correlation with the clinical forms of leprosy, as well as their implications for disease resistance and susceptibility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jarduli, Luciana Ribeiro& Sell, Ana Maria& Reis, Pâmela Guimarães& Sippert, Emília Ângela& Ayo, Christiane Maria& Mazini, Priscila Saamara…[et al.]. 2013. Role of HLA, KIR, MICA, and Cytokines Genes in Leprosy. BioMed Research International،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-1031174
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jarduli, Luciana Ribeiro…[et al.]. Role of HLA, KIR, MICA, and Cytokines Genes in Leprosy. BioMed Research International No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-1031174
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jarduli, Luciana Ribeiro& Sell, Ana Maria& Reis, Pâmela Guimarães& Sippert, Emília Ângela& Ayo, Christiane Maria& Mazini, Priscila Saamara…[et al.]. Role of HLA, KIR, MICA, and Cytokines Genes in Leprosy. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-1031174
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031174
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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