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Early Complication in Sickle Cell Anemia Children due to A(TA)nTAA Polymorphism at the Promoter of UGT1A1 Gene
المؤلفون المشاركون
Abbes, Salem
Chaouch, Leila
Talbi, Emna
Ben Chaabene, Arij
Kalai, Miniar
Chaouachi, Dorra
Mallouli, Fethi
Ghanem, Abderraouf
Moumni, Imen
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aim.
To determine the implication of the polymorphism, namely, A(TA)nTAA of UGT1A1 in lithogenesis for the first time in Tunisia among sickle cell anemia (SCA) children patients.
Material and Methods.
Our study was performed in 2010 and it involved 76 subjects chosen as control group characterized with normal hemoglobin status and presence of cholelithiasis and 102 SCA pediatric patients among whom 52 have cholelithiasis.
We analyzed the polymorphism A(TA)nTAA at the UGT1A1 promoter and the relationships between the various A(TA)nTAA genotypes and alleles and bilirubin levels and occurrence of cholelithiasis.
Results and Discussion.
The repartition of genotypes found according to serum bilirubin level shows a significant association between genotypes carrying variant (TA)7 and hyperbilirubinemia (P<0.05).
We demonstrated the association of two genotypes with gallstones formation among SCA children patients: (TA)7/(TA)7 and (TA)7/(TA)8 with P=8.1×10-8 and P=0.01, respectively.
(TA)7 and (TA)8 allele variants act as a risk factor for early gallstones formation in SCA patients with P=5.8×10-9 and P=0.01, respectively.
As for the control group only the genotype (TA)7/(TA)7 presented a risk factor for gallstones formation.
Conclusion.
The novelty of this report is that it is the first time that a similar study was made on the Tunisian children sickle cell population and that the results show a clear association of (TA)7 variant in early gallstones formation in Tunisian SCA children.
Interestingly our findings highlighted the association of (TA)8 variant as well, which was not found in previous studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chaouch, Leila& Talbi, Emna& Moumni, Imen& Ben Chaabene, Arij& Kalai, Miniar& Chaouachi, Dorra…[et al.]. 2013. Early Complication in Sickle Cell Anemia Children due to A(TA)nTAA Polymorphism at the Promoter of UGT1A1 Gene. Disease Markers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031186
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chaouch, Leila…[et al.]. Early Complication in Sickle Cell Anemia Children due to A(TA)nTAA Polymorphism at the Promoter of UGT1A1 Gene. Disease Markers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031186
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chaouch, Leila& Talbi, Emna& Moumni, Imen& Ben Chaabene, Arij& Kalai, Miniar& Chaouachi, Dorra…[et al.]. Early Complication in Sickle Cell Anemia Children due to A(TA)nTAA Polymorphism at the Promoter of UGT1A1 Gene. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031186
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031186
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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