Immune Activation and Viral Replication after Vaccination with an Influenza A H1N1 2009 Vaccine in HIV-Infected Children Receiving Antiretroviral Therapy
المؤلفون المشاركون
Unpol, Petai
Boonchan, Michittra
Sukapirom, Kasama
Wittawatmongkol, Orasri
Chokephaibulkit, Kulkanya
Ammaranond, Palanee
Pattanapanyasat, Kovit
Onlamoon, Nattawat
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Immunization with a pandemic influenza A H1N1 2009 was recommended for HIV-infected patients.
However, there is limited information concerning the impact of immunization with this vaccine on immune activation and HIV viral replication.
In this study, 45 HIV-infected children and adolescents receiving antiretroviral therapy were immunized with a 2-dose series of nonadjuvated monovalent influenza A H1N1 2009 vaccine upon enrollment and approximately 1 month later.
Immunogenicity was determined by haemagglutination inhibition assay.
The level of immune activation was determined by identification of CD38 and HLA-DR on CD8+ T cells.
Patients were divided into 2 groups which include patients who had an undetectable HIV viral load (HIV detectable group) and patients who show virological failure (HIV nondetectable group).
The results showed seroconversion rate of 55.2% in HIV nondetectable group, whereas 31.3% was found in HIV detectable group.
Both groups of patients showed no major increase in immune activation after immunization.
Interestingly, a decrease in the frequency of CD8+ T cells that coexpressed CD38 and HLA-DR was observed after immunization in both groups of patients.
We suggested that immunization with influenza A H1N1 2009 vaccine can induce immune response to the pandemic virus without major impact on HIV viral replication and immune activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Onlamoon, Nattawat& Unpol, Petai& Boonchan, Michittra& Sukapirom, Kasama& Wittawatmongkol, Orasri& Chokephaibulkit, Kulkanya…[et al.]. 2013. Immune Activation and Viral Replication after Vaccination with an Influenza A H1N1 2009 Vaccine in HIV-Infected Children Receiving Antiretroviral Therapy. Disease Markers،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031192
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Onlamoon, Nattawat…[et al.]. Immune Activation and Viral Replication after Vaccination with an Influenza A H1N1 2009 Vaccine in HIV-Infected Children Receiving Antiretroviral Therapy. Disease Markers No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031192
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Onlamoon, Nattawat& Unpol, Petai& Boonchan, Michittra& Sukapirom, Kasama& Wittawatmongkol, Orasri& Chokephaibulkit, Kulkanya…[et al.]. Immune Activation and Viral Replication after Vaccination with an Influenza A H1N1 2009 Vaccine in HIV-Infected Children Receiving Antiretroviral Therapy. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031192
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031192
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر