![](/images/graphics-bg.png)
Association of TAP Gene Polymorphisms and Risk of Cervical Intraepithelial Neoplasia
المؤلفون المشاركون
Natter, Camilla
Polterauer, Stephan
Rahhal-Schupp, Jasmin
Pils, Sophie
Speiser, Paul
Heinze, Georg
Grimm, Christoph
Tong, D.
Zeillinger, Robert
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Transporter associated with antigen processing (TAP) is responsible for peptide loading onto class I major histocompatibility complex (MHC-I) molecules.
TAP seems to facilitate the detection of HPV by MHC-I molecules and contributes to successful eradication of HPV.
TAP polymorphisms could have an important impact on the course of HPV infection.
Objective.
The aim of this study is to evaluate the association between five TAP gene polymorphisms and the risk of CIN.
Methods.
This case-control study investigated five common TAP polymorphisms in TAP1 (1341 and 2254) and TAP2 (1135, 1693, and 1993) in 616 women with CIN and 206 controls.
Associations between gene polymorphisms and risk of CIN were analysed by univariate and multivariable models.
The combined effect of the five TAP gene polymorphisms on the risk for CIN was investigated by haplotype analysis.
Results.
No significant difference in genotype distribution of the five TAP polymorphisms was observed in women with CIN and controls.
Haplotype analysis revealed that women with haplotype mut-wt-wt-wt-wt (TAP polymorphisms t1135-t1341-t1693-t1993-t2254) had a significantly lower risk for CIN, compared to women with the haplotype wt-wt-wt-wt-wt (P=0.006; OR 0.5 [0.35–0.84]).
Conclusion.
Identification of this haplotype combination could be used to identify women, less susceptible for development of CIN following HPV infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Natter, Camilla& Polterauer, Stephan& Rahhal-Schupp, Jasmin& Tong, D.& Pils, Sophie& Speiser, Paul…[et al.]. 2013. Association of TAP Gene Polymorphisms and Risk of Cervical Intraepithelial Neoplasia. Disease Markers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031197
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Natter, Camilla…[et al.]. Association of TAP Gene Polymorphisms and Risk of Cervical Intraepithelial Neoplasia. Disease Markers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1031197
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Natter, Camilla& Polterauer, Stephan& Rahhal-Schupp, Jasmin& Tong, D.& Pils, Sophie& Speiser, Paul…[et al.]. Association of TAP Gene Polymorphisms and Risk of Cervical Intraepithelial Neoplasia. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1031197
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031197
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)