Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value
المؤلفون المشاركون
Tseng, Chia-Cheng
Tsai, Tzu-Hsien
Chang, Huang-Chih
Chang, Li-Teh
Yip, Hon-Kan
Liu, Shih-Feng
Chen, Chih-Hung
Lin, Meng-Chih
Huang, Kuo-Tung
Wang, Chin-Chou
Leu, Steve
Yen, Chia-Hung
Yang, Cheng-Ta
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Endothelial-derived microparticles (EDMPs) and platelet-derived microparticles (PDMPs) have been reported to be increasing in various diseases including malignant diseases.
Here, we investigated whether these MPs may be useful biomarkers for predicting lung cancer (LC) disease status, cell type, or metastasis.
Methods and Results.
One hundred and thirty LC patients were prospectively enrolled into the study between April 2011 and February 2012.
Flow cytometric analysis demonstrated that the circulating levels of platelet-derived activated MPs (PDAc-MPs), platelet-derived apoptotic MPs (PDAp-MPs), endothelial-derived activated MPs (EDAc-MPs), and endothelial-derived apoptotic MPs (EDAp-MPs) were significantly higher in LC patients than in 30 age- and gender-matched normal control subjects (all P<0.05).
Additionally, circulating level of PDAc-MPs was significantly lower (P=0.031), whereas the circulating levels of the other three biomarkers did not differ (all P>0.1) in early stage versus late stage LC patients.
Furthermore, the circulating levels of the four types of MPs did not differ among patients with different disease statuses (i.e., disease controlled, disease progression, and disease without treatment, i.e., fresh case) (all P>0.2) or between patients with or without LC metastasis (all P>0.5).
Moreover, only the circulating level of EDAp-MPs was significantly associated with the different cell types (i.e., squamous cell carcinoma, adenocarcinoma, and small cell carcinoma) of LC (P=0.045).
Conclusion.
Circulating MP levels are significantly increased in LC patients as compared with normal subjects.
Among the MPs, only an increased level of EDAp-MPs was significantly associated with different LC cell types.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tseng, Chia-Cheng& Wang, Chin-Chou& Chang, Huang-Chih& Tsai, Tzu-Hsien& Chang, Li-Teh& Huang, Kuo-Tung…[et al.]. 2013. Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value. Disease Markers،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031220
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tseng, Chia-Cheng…[et al.]. Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value. Disease Markers No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1031220
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tseng, Chia-Cheng& Wang, Chin-Chou& Chang, Huang-Chih& Tsai, Tzu-Hsien& Chang, Li-Teh& Huang, Kuo-Tung…[et al.]. Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031220
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031220
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر