Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3
المؤلفون المشاركون
Chen, Yi-Chun
Chen, Chiung-Mei
Chen, Wan-Ling
Wu, Yi-Ci
Lee, Li-Ching
Lin, Te-Hsien
Wu, Yih-Ru
Kung, Pin-Jui
Lee-Chen, Guey-Jen
Lin, Chih-Hsin
Chang, Kuo-Hsuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Spinocerebellar ataxia (SCA) types 1, 2, 3, 6, 7, and 17 as well as Huntington’s disease are a group of neurodegenerative disorders caused by expanded CAG repeats encoding a long polyglutamine (polyQ) tract in the respective proteins.
Evidence has shown that the accumulation of intranuclear and cytoplasmic misfolded polyQ proteins leads to apoptosis and cell death.
Thus suppression of aggregate formation is expected to inhibit a wide range of downstream pathogenic events in polyQ diseases.
In this study, we established a high-throughput aggregation screening system using 293 ATXN3/Q75-GFP cells and applied this system to test the aqueous extract of Paeonia lactiflora (P.
lactiflora) and its constituents.
We found that the aggregation can be significantly prohibited by P.
lactiflora and its active compound paeoniflorin.
Meanwhile, P.
lactiflora and paeoniflorin upregulated HSF1 and HSP70 chaperones in the same cell models.
Both of them further reduced the aggregation in neuronal differentiated SH-SY5Y ATXN3/Q75-GFP cells.
Our results demonstrate how P.
lactiflora and paeoniflorin are likely to work on polyQ-aggregation reduction and provide insight into the possible working mechanism of P.
lactiflora in SCA3.
We anticipate our paper to be a starting point for screening more potential herbs for the treatment of SCA3 and other polyQ diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Kuo-Hsuan& Chen, Wan-Ling& Lee, Li-Ching& Lin, Chih-Hsin& Kung, Pin-Jui& Lin, Te-Hsien…[et al.]. 2013. Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1031250
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Kuo-Hsuan…[et al.]. Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1031250
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Kuo-Hsuan& Chen, Wan-Ling& Lee, Li-Ching& Lin, Chih-Hsin& Kung, Pin-Jui& Lin, Te-Hsien…[et al.]. Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1031250
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031250
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر