Development of Lecithin Nanoemulsion Based Organogels for Permeation Enhancement of Metoprolol through Rat Skin
المؤلفون المشاركون
Varshosaz, Jaleh
Tabbakhian, Majid
Andalib, S.
Ebrahimzadeh, N.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Drugs with low oral bioavailability due to the first pass metabolism are good candidates for transdermal delivery.
Objectives.
The aim of this work was preparation of transdermal nanoemulsion of metoprolol which has high first pass metabolism.
Methods.
Three commercially available types of lecithin (200, 100p, and 170), three short chain alcohol (n-butanol, isopropyl alcohol, and n-propanol), and isopropyl myristate (IPM) were used as surfactant, cosurfactant, and oil phase, respectively.
The aqueous phase was composed of metoprolol tartrate.
Nanoemulsions with different surfactant/cosurfactant weight ratio, various amounts of drug, and different types of alcohol were prepared, and their phase diagrams were studied.
Drug release, permeability, and diffusion coefficient of the drug were studied using hairless rat skin.
Results.
A significant increase in drug solution rate was observed with increasing the metoprolol content in the nanoemulsions, while it decreased when lecithin concentration increased from 40% to 60%.
Increasing the water content resulted in a significant increase in metoprolol release.
N-butanol enhanced the drug flux from nanoemulsions more than n-propanol and isopropyl alcohol.
The o/w nanoemulsions of metoprolol showed high flux and permeability through the skin.
Conclusion.
Both w/o and o/w nanoemulsions of metoprolol could enhance permeation and diffusion of metoprolol through rat skin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Varshosaz, Jaleh& Andalib, S.& Tabbakhian, Majid& Ebrahimzadeh, N.. 2013. Development of Lecithin Nanoemulsion Based Organogels for Permeation Enhancement of Metoprolol through Rat Skin. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031307
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Varshosaz, Jaleh…[et al.]. Development of Lecithin Nanoemulsion Based Organogels for Permeation Enhancement of Metoprolol through Rat Skin. Journal of Nanomaterials No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1031307
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Varshosaz, Jaleh& Andalib, S.& Tabbakhian, Majid& Ebrahimzadeh, N.. Development of Lecithin Nanoemulsion Based Organogels for Permeation Enhancement of Metoprolol through Rat Skin. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1031307
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031307
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر