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Microwave Mediated Organic Reaction: A Convenient Approach for Rapid and Efficient Synthesis of Biologically Active Substituted 1,3-Dihydro-2H-indol-2-one Derivatives
المؤلفون المشاركون
Mishra, Nikunja Kishor
Padhi, Sai Krushna
Mishra, Jitendriya
Sahoo, Biswa Mohan
Panda, Jnyanaranjan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
A simple and efficient method has been developed for the synthesis of 1,3-dihydro-2H-indol-2-one derivatives using microwave irradiation technique.
By taking advantage of the efficient source of energy of microwave, compound libraries for lead generation and optimization can be assembled in a fraction of time.
In the present work, first the Schiff’s bases are synthesized by reaction of isatin with substituted anilines in the presence of acetic acid under microwave heating.
Then the condensation of Schiff bases with different secondary amines in the presence of formaldehyde produces Mannich bases.
The newly synthesized Mannich bases were characterized by means of spectral data and then evaluated for anthelmintic activity against Pheretima posthuma (Indian earthworm) and compared with standard albendazole.
The compounds were evaluated at the concentrations of 10, 20, and 50 mg/mL.
The effect of the standard drug albendazole at 10 mg/mL was also evaluated.
The results of the present study indicate that some of the test compounds significantly demonstrated paralysis and also caused death of worms in a dose-dependent manner.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Panda, Jnyanaranjan& Sahoo, Biswa Mohan& Mishra, Nikunja Kishor& Padhi, Sai Krushna& Mishra, Jitendriya. 2013. Microwave Mediated Organic Reaction: A Convenient Approach for Rapid and Efficient Synthesis of Biologically Active Substituted 1,3-Dihydro-2H-indol-2-one Derivatives. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031331
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Panda, Jnyanaranjan…[et al.]. Microwave Mediated Organic Reaction: A Convenient Approach for Rapid and Efficient Synthesis of Biologically Active Substituted 1,3-Dihydro-2H-indol-2-one Derivatives. Journal of Nanomaterials No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1031331
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Panda, Jnyanaranjan& Sahoo, Biswa Mohan& Mishra, Nikunja Kishor& Padhi, Sai Krushna& Mishra, Jitendriya. Microwave Mediated Organic Reaction: A Convenient Approach for Rapid and Efficient Synthesis of Biologically Active Substituted 1,3-Dihydro-2H-indol-2-one Derivatives. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1031331
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031331
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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