Combined Effects of Mechanical Strain and HydroxyapatiteCollagen Composite on Osteogenic Differentiation of Rat Bone Marrow Derived Mesenchymal Stem Cells
المؤلفون المشاركون
Song, Wei
Fan, Yubo
Huang, Yan
Niu, Xufeng
Guan, Changdong
Feng, Qingling
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Mesenchymal stem cells (MSCs) represent a promising source for bone repair and regeneration.
Recent lines of evidence have shown that appropriate strain could regulate the osteogenic differentiation of MSCs.
Our previous study demonstrated that hydroxyapatite/collagen (HA/Col) composite also played an important role in the osteogenic differentiation of MSCs.
The aim of this study is to investigate the effects of mechanical strain and HA/Col composite on the osteogenic differentiation of rat bone marrow derived MSCs (rBMSCs) in vitro.
rBMSCs were treated with cyclic strain generated by a self-designed stretching device with or without the presence of HA/Col composite.
Osteogenic differentiation levels were evaluated using reverse transcription polymerase chain reaction (RT-PCR), alkaline phosphatase spectrophotometry, and western blotting.
The results demonstrated that mechanical strain combined with HA/Col composite could obviously induce the differentiation of rBMSCs into osteoblasts, which had a better effect than only mechanical strain or HA/Col composite treatment.
This provides a new avenue for mechanistic studies of stem cell differentiation and a novel approach to obtain more committed differentiated cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Yan& Niu, Xufeng& Song, Wei& Guan, Changdong& Feng, Qingling& Fan, Yubo. 2013. Combined Effects of Mechanical Strain and HydroxyapatiteCollagen Composite on Osteogenic Differentiation of Rat Bone Marrow Derived Mesenchymal Stem Cells. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031342
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Yan…[et al.]. Combined Effects of Mechanical Strain and HydroxyapatiteCollagen Composite on Osteogenic Differentiation of Rat Bone Marrow Derived Mesenchymal Stem Cells. Journal of Nanomaterials No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031342
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Yan& Niu, Xufeng& Song, Wei& Guan, Changdong& Feng, Qingling& Fan, Yubo. Combined Effects of Mechanical Strain and HydroxyapatiteCollagen Composite on Osteogenic Differentiation of Rat Bone Marrow Derived Mesenchymal Stem Cells. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031342
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031342
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر