Novel Caffeic Acid Nanocarrier: Production, Characterization, and Release Modeling
المؤلفون المشاركون
Varshosaz, Jaleh
Fathi, Milad
Mirlohi, Maryam
Madani, Golnoosh
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This paper deals with the development of novel nanocarriers using layer by layer carbohydrate coating of caffeic acid loaded solid lipid nanoparticles (SLNs) to improve stability and colon delivery of the poorly water-soluble caffeic acid.
Three biopolymers (chitosan, alginate, and pectin) in different concentrations (0.1, 0.25, and 0.5%) were electrostatically coated over the SLN surface.
The size and zeta potential of produced nanocarriers were measured using photon correlation spectroscopy.
Mathematical models (i.e., zero-order, first-order, Higuchi, Ritger-Peppas, reciprocal powered time, Weibull, and quadratic models) were used to describe the release and kinetic modeling in gastrointestinal solution (GIS).
Also, antioxidant activity of caffeic acid during the release in GIS was investigated using DPPH and reducing activity methods.
The prepared treatments coated by alginate-chitosan as well as pectin-chitosan coated SLN at the concentration of 0.1% showed nanosized bead; the latter efficiently retarded the release of caffeic acid in gastric media up to 2.5 times higher than that of SLN.
Zeta potential values of coated samples were found to significantly increase in comparison to SLN indicating the higher stability of produced nanocarriers.
Antioxidant activity of caffeic acid after gastric release did not result in the same trend as observed for caffeic acid release from different treatments; however, in line with less caffeic acid release in the intestine solution by the effect of coating, lower antioxidant activity was determined at the end stage of the experiment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fathi, Milad& Mirlohi, Maryam& Varshosaz, Jaleh& Madani, Golnoosh. 2013. Novel Caffeic Acid Nanocarrier: Production, Characterization, and Release Modeling. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031382
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fathi, Milad…[et al.]. Novel Caffeic Acid Nanocarrier: Production, Characterization, and Release Modeling. Journal of Nanomaterials No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1031382
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fathi, Milad& Mirlohi, Maryam& Varshosaz, Jaleh& Madani, Golnoosh. Novel Caffeic Acid Nanocarrier: Production, Characterization, and Release Modeling. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1031382
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031382
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر