Triple-Component Drug-Loaded Nanocomposites Prepared Using a Modified Coaxial Electrospinning

المؤلفون المشاركون

Li, Xiao-Yan
Yu, Deng-Guang
Qian, Wei
Li, Ying
Liao, Yao-Zu
Wang, Xia

المصدر

Journal of Nanomaterials

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-12-22

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الكيمياء
هندسة مدنية

الملخص EN

Triple-component nanocomposites for improved sustained drug release profiles are successfully fabricated through a modified coaxial electrospinning process, in which only organic solvent N,N-dimethylacetamide was used as sheath fluid.

Using polyacrylonitrile (PAN) as filament-forming matrix, ibuprofen (IBU) as functional ingredient, and polyvinylpyrrolidone (PVP) as the additional component, the IBU/PVP/PAN triple-component nanocomposites had uniform structure and an average diameter of 620±120 nm and 650±120 nm when the contents of PVP in the nanofibers were 10.5% and 22.7%, respectively.

The optimal sheath-to-core flow rate ratio was 0.11 under a total sheath and core fluid flow rate of 1.0 mL/h.

Compared with the IBU/PAN composite nanofibers, the triple-component composites could release 92.1% and 97.8% of the contained IBU, significantly larger than a value of 73.4% from the former.

The inclusion of PVP in the IBU/PAN could effectively avoid the entrapment of IBU in the insoluble PAN molecules, facilitating the in vitro release of IBU.

The modified coaxial process and the resulted multiple component nanocomposites would provide new way for developing novel drug sustained materials and transdermal drug delivery systems.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Qian, Wei& Yu, Deng-Guang& Li, Ying& Li, Xiao-Yan& Liao, Yao-Zu& Wang, Xia. 2013. Triple-Component Drug-Loaded Nanocomposites Prepared Using a Modified Coaxial Electrospinning. Journal of Nanomaterials،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031589

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Qian, Wei…[et al.]. Triple-Component Drug-Loaded Nanocomposites Prepared Using a Modified Coaxial Electrospinning. Journal of Nanomaterials No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031589

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Qian, Wei& Yu, Deng-Guang& Li, Ying& Li, Xiao-Yan& Liao, Yao-Zu& Wang, Xia. Triple-Component Drug-Loaded Nanocomposites Prepared Using a Modified Coaxial Electrospinning. Journal of Nanomaterials. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031589

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1031589