Magnetic Properties and Biological Activity Evaluation of Iron Oxide Nanoparticles

الملخص EN

The aim of this study was to provide information about the biological properties of iron oxide nanoparticles (IO-NPs) obtained in an aqueous suspension.

The IO-NPs were characterized by transmission electron microscopy (TEM).

Analysis of hysteresis loops data at room temperature for magnetic IO-NPs sample indicated that the IO-NPs were superparamagnetic at room temperature.

The calculated saturation magnetization for magnetic iron oxide was Ms = 18.1 emu/g.

The antimicrobial activity of the obtained PMC-NPs was tested against Gram-negative (Pseudomonas aeruginosa 1397, Escherichia coli ATCC 25922), Gram-positive (Enterococcus faecalis ATCC 29212, Bacillus subtilis IC 12488) bacterial as well as fungal (Candida krusei 963) strains.

The obtained results suggested that the antimicrobial activity of IO-NPs is dependent on the metallic ions concentrations and on the microbial growth state, either planktonic or adherent.

The obtained IO-NPs exhibited no cytotoxic effect on HeLa cells at the active antimicrobial concentrations.