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Identification of Protein Pupylation Sites Using Bi-Profile Bayes Feature Extraction and Ensemble Learning
المؤلفون المشاركون
Ning, Qiao
Zhang, Jian
Zhao, Xiaowei
Ma, Zhiqiang
Yin, Minghao
Sun, Pingping
المصدر
Mathematical Problems in Engineering
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Pupylation, one of the most important posttranslational modifications of proteins, typically takes place when prokaryotic ubiquitin-like protein (Pup) is attached to specific lysine residues on a target protein.
Identification of pupylation substrates and their corresponding sites will facilitate the understanding of the molecular mechanism of pupylation.
Comparing with the labor-intensive and time-consuming experiment approaches, computational prediction of pupylation sites is much desirable for their convenience and fast speed.
In this study, a new bioinformatics tool named EnsemblePup was developed that used an ensemble of support vector machine classifiers to predict pupylation sites.
The highlight of EnsemblePup was to utilize the Bi-profile Bayes feature extraction as the encoding scheme.
The performance of EnsemblePup was measured with a sensitivity of 79.49%, a specificity of 82.35%, an accuracy of 85.43%, and a Matthews correlation coefficient of 0.617 using the 5-fold cross validation on the training dataset.
When compared with other existing methods on a benchmark dataset, the EnsemblePup provided better predictive performance, with a sensitivity of 80.00%, a specificity of 83.33%, an accuracy of 82.00%, and a Matthews correlation coefficient of 0.629.
The experimental results suggested that EnsemblePup presented here might be useful to identify and annotate potential pupylation sites in proteins of interest.
A web server for predicting pupylation sites was developed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Xiaowei& Zhang, Jian& Ning, Qiao& Sun, Pingping& Ma, Zhiqiang& Yin, Minghao. 2013. Identification of Protein Pupylation Sites Using Bi-Profile Bayes Feature Extraction and Ensemble Learning. Mathematical Problems in Engineering،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031779
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Xiaowei…[et al.]. Identification of Protein Pupylation Sites Using Bi-Profile Bayes Feature Extraction and Ensemble Learning. Mathematical Problems in Engineering No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1031779
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Xiaowei& Zhang, Jian& Ning, Qiao& Sun, Pingping& Ma, Zhiqiang& Yin, Minghao. Identification of Protein Pupylation Sites Using Bi-Profile Bayes Feature Extraction and Ensemble Learning. Mathematical Problems in Engineering. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1031779
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1031779
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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